User profiles for Yohan Bossé
 | Yohan BosséProfessor at Université Laval Verified email at criucpq.ulaval.ca Cited by 19024 |
Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
[HTML][HTML] An integrated cell atlas of the lung in health and disease
…, M van den Berge, Y Bossé… - Nature Medicine, 2023 - nature.com
Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions. …
typically capture only a limited number of donors and disagree on cell type definitions. …
[HTML][HTML] Tobacco smoking increases the lung gene expression of ACE2, the receptor of SARS-CoV-2
Methods We evaluated a comprehensive set of transcriptomic data sets to investigate the
associations of smoking with ACE2, FURIN, and TMPRSS2 gene expression in lung tissues. …
associations of smoking with ACE2, FURIN, and TMPRSS2 gene expression in lung tissues. …
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
Although several lung cancer susceptibility loci have been identified, much of the heritability
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …
Bicuspid aortic valve: identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon)
…, MM Bissell, N Anavekar, P Mathieu, Y Bossé… - Circulation, 2014 - Am Heart Assoc
Given the high incidence of BAV dysfunction requiring surgical intervention and the high
incidence of associated TAA formation8–10, 14–18 (Table), the BAV condition should be …
incidence of associated TAA formation8–10, 14–18 (Table), the BAV condition should be …
[HTML][HTML] Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in …
Background Understanding the genetic basis of airflow obstruction and smoking behaviour
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). …
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). …
[HTML][HTML] Lung eQTLs to help reveal the molecular underpinnings of asthma
Genome-wide association studies (GWAS) have identified loci reproducibly associated with
pulmonary diseases; however, the molecular mechanism underlying these associations are …
pulmonary diseases; however, the molecular mechanism underlying these associations are …
Oxidized phospholipids, lipoprotein (a), and progression of calcific aortic valve stenosis
…, KL Chan, C Yeang, P Mathieu, Y Bossé… - Journal of the American …, 2015 - jacc.org
Background : Elevated lipoprotein(a) (Lp[a]) is associated with aortic stenosis (AS). Oxidized
phospholipids (OxPL) are key mediators of calcification in valvular cells and are carried by …
phospholipids (OxPL) are key mediators of calcification in valvular cells and are carried by …
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide 1 .
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …