[HTML][HTML] Insulin-regulated serine and lipid metabolism drive peripheral neuropathy
…, CR Green, LS Guernsey, T Lin, P Tseng, Y Ideguchi… - Nature, 2023 - nature.com
Diabetes represents a spectrum of disease in which metabolic dysfunction damages multiple
organ systems including liver, kidneys and peripheral nerves 1 , 2 . Although the onset and …
organ systems including liver, kidneys and peripheral nerves 1 , 2 . Although the onset and …
[HTML][HTML] Serine and lipid metabolism in macular disease and peripheral neuropathy
…, TFC Heeren, L Sauer, Y Ideguchi… - … England Journal of …, 2019 - Mass Medical Soc
Background Identifying mechanisms of diseases with complex inheritance patterns, such as
macular telangiectasia type 2, is challenging. A link between macular telangiectasia type 2 …
macular telangiectasia type 2, is challenging. A link between macular telangiectasia type 2 …
[HTML][HTML] Novel cerebello-amygdala connections provide missing link between cerebellum and limbic system
…, M Anguiano, Y Ideguchi… - Frontiers in systems …, 2022 - frontiersin.org
The cerebellum is emerging as a powerful regulator of cognitive and affective processing and
memory in both humans and animals and has been implicated in affective disorders. How …
memory in both humans and animals and has been implicated in affective disorders. How …
Deletion of Tgfβ signal in activated microglia prolongs hypoxia‐induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis
Retinal neovascularization (NV) is the major cause of severe visual impairment in patients
with ischemic eye diseases. While it is known that retinal microglia contribute to both …
with ischemic eye diseases. While it is known that retinal microglia contribute to both …
[HTML][HTML] Bioactive extracellular vesicles from a subset of endothelial progenitor cells rescue retinal ischemia and neurodegeneration
Disruption of the neurovascular unit (NVU) underlies the pathophysiology of various CNS
diseases. One strategy to repair NVU dysfunction uses stem/progenitor cells to provide trophic …
diseases. One strategy to repair NVU dysfunction uses stem/progenitor cells to provide trophic …
[HTML][HTML] Retinal microglia are critical for subretinal neovascular formation
…, Y Usui, T Kurihara, E Aguilar, MI Dorrell, Y Ideguchi… - JCI insight, 2020 - ncbi.nlm.nih.gov
Abnormal subretinal neovascularization is a characteristic of vision-threatening retinal
diseases, including macular telangiectasia (MacTel) and retinal angiomatous proliferation (RAP). …
diseases, including macular telangiectasia (MacTel) and retinal angiomatous proliferation (RAP). …
[HTML][HTML] Development of a Semi-automated Computer-based Tool for the Quantification of Vascular Tortuosity in the Murine Retina
Purpose The murine oxygen-induced retinopathy (OIR) model is one of the most widely used
animal models of ischemic retinopathy, mimicking hallmark pathophysiology of initial vaso-…
animal models of ischemic retinopathy, mimicking hallmark pathophysiology of initial vaso-…
Vascular tortuosity quantification as an outcome metric of the oxygen-induced retinopathy model of ischemic retinopathy
The murine oxygen-induced retinopathy (OIR) model is one of the most widely used animal
models of ischemic retinopathy, mimicking hallmark pathophysiology of initial vaso-…
models of ischemic retinopathy, mimicking hallmark pathophysiology of initial vaso-…
[HTML][HTML] Application of deep learning to quantify vascular tortuosity in mouse models of oxygen-induced retinopathy
Purpose: Increased retinal vascular tortuosity has been quantified in retinal images of humans
with retinopathy of prematurity (ROP). The oxygen-induced retinopathy (OIR) model of …
with retinopathy of prematurity (ROP). The oxygen-induced retinopathy (OIR) model of …
[HTML][HTML] Impaired ceramide metabolism is associated with retinal changes in a model of tamoxifen retinopathy
…, ED Rubio, C Bates, Y Ideguchi… - … & Visual Science, 2023 - iovs.arvojournals.org
Purpose: Tamoxifen is a selective estrogen receptor modulator used to treat breast cancer
and other conditions. Tamoxifen retinopathy (TR) is a side effect of long-term tamoxifen intake …
and other conditions. Tamoxifen retinopathy (TR) is a side effect of long-term tamoxifen intake …