Mechanisms of toxicity in C9FTLD/ALS
A hexanucleotide repeat expansion within a non-coding region of the C9ORF72 gene is the
most common mutation causative of frontotemporal lobar degeneration (FTLD) and …
most common mutation causative of frontotemporal lobar degeneration (FTLD) and …
[HTML][HTML] Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue
L Liu-Yesucevitz, A Bilgutay, YJ Zhang, T Vanderwyde… - PloS one, 2010 - journals.plos.org
Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases
of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). TDP-…
of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). TDP-…
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
YJ Zhang, YF Xu, C Cook… - Proceedings of the …, 2009 - National Acad Sciences
Inclusions of TAR DNA-binding protein-43 (TDP-43), a nuclear protein that regulates
transcription and RNA splicing, are the defining histopathological feature of frontotemporal lobar …
transcription and RNA splicing, are the defining histopathological feature of frontotemporal lobar …
Probing primordial gravitational waves: Ali CMB polarization telescope
…, CZ Liu, ZW Li, H Xu, D Wu, YJ Zhang… - National Science …, 2019 - academic.oup.com
In this paper, we will give a general introduction to the Ali CMB Polarization Telescope (AliCPT)
project, which is a Sino–US joint project led by the Institute of High Energy Physics and …
project, which is a Sino–US joint project led by the Institute of High Energy Physics and …
[HTML][HTML] Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD …
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are devastating
neurodegenerative disorders with clinical, genetic, and neuropathological overlap. A …
neurodegenerative disorders with clinical, genetic, and neuropathological overlap. A …
Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice
YF Xu, TF Gendron, YJ Zhang, WL Lin… - Journal of …, 2010 - Soc Neuroscience
Transactivation response DNA-binding protein 43 (TDP-43) is a principal component of
ubiquitinated inclusions in frontotemporal lobar degeneration with ubiquitin-positive inclusions …
ubiquitinated inclusions in frontotemporal lobar degeneration with ubiquitin-positive inclusions …
[HTML][HTML] Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis
NJ Rutherford, YJ Zhang, M Baker, JM Gass… - PLoS …, 2008 - journals.plos.org
The TAR DNA-binding protein 43 (TDP-43) has been identified as the major disease protein
in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin …
in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin …
[HTML][HTML] TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43)
is a common histopathological hallmark of the amyotrophic lateral sclerosis and …
is a common histopathological hallmark of the amyotrophic lateral sclerosis and …
C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits
The major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis is a G
4 C 2 repeat expansion in C9ORF72. Efforts to combat neurodegeneration associated with “…
4 C 2 repeat expansion in C9ORF72. Efforts to combat neurodegeneration associated with “…
Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43
TAR DNA binding protein-43 (TDP-43) is the pathologic substrate of neuronal and glial
inclusions in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTDL-U) and …
inclusions in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTDL-U) and …