Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …

Although there is growing evidence that high performance work practices (HPWPs) affect
organizational performance, varying sample characteristics, research designs, practices …

Background Vitamin D is crucial for maintenance of musculoskeletal health, and might also
have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D …

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …

Background Limited information is available regarding genetic contributions to valvular
calcification, which is an important precursor of clinical valve disease. Methods We determined …

A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …

ContextTotal cholesterol level is inversely associated with mortality in dialysis patients, a group
at high risk of cardiovascular disease (CVD). This paradox may be explained by systemic …

Recent genome-wide association studies have described many loci implicated in type 2
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the …

Through genome-wide association meta-analyses of up to 133,010 individuals of European
ancestry without diabetes, including individuals newly genotyped using the Metabochip, we …

Signaling pathways transmit information through protein interaction networks that are
dynamically regulated by complex extracellular cues. We developed LUMIER (for luminescence-…