Although the protein synthesis inhibitor cycloheximide (CHX) has been known for decades,
its precise mechanism of action remains incompletely understood. The glutarimide portion of …

Cancer-associated fibroblasts (CAF) are components of the tumor microenvironment whose
contributions to malignant progression are not fully understood. Here, we show that the …

Triptolide ( 1 ) is a structurally unique diterpene triepoxide isolated from a traditional Chinese
medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor …

The molecular machinery required for autophagy is highly conserved in all eukaryotes as
seen by the high degree of conservation of proteins involved in the formation of the …

Accumulation of mutant proteins is a major cause of many diseases (collectively called
proteopathies), and lowering the level of these proteins can be useful for treatment of these …

Stress granules are aggregates of small ribosomal subunits, mRNA, and numerous associated
RNA-binding proteins that include several translation initiation factors. Stress granule …

Translation initiation in eukaryotes is accomplished through the coordinated and orderly
action of a large number of proteins, including the eIF4 initiation factors. Herein, we report that …

The targeted degradation of membrane proteins would afford an attractive and general
strategy for treating various diseases that remain difficult with the current proteolysis-targeting …

Mammalian target of rapamycin (mTOR) constitutes a nodal point of a signaling network that
regulates cell growth and proliferation in response to various environmental cues ranging …

Rat microtubule-associated protein light chain 3 (LC3) is a homologue of yeast Atg8, an
essential component of autophagy. Following synthesis, the C-terminus of rat LC3 is cleaved by …