Pyruvate-responsive genetic circuits for dynamic control of central metabolism

X Xu, X Li, Y Liu, Y Zhu, J Li, G Du, J Chen… - Nature Chemical …, 2020 - nature.com
Dynamic regulation is a promising strategy for fine-tuning metabolic fluxes in microbial cell
factories. However, few of these synthetic regulatory systems have been developed for …

Engineering Yarrowia lipolytica as a Chassis for De Novo Synthesis of Five Aromatic-Derived Natural Products and Chemicals

Y Gu, J Ma, Y Zhu, X Ding, P Xu - ACS synthetic biology, 2020 - ACS Publications
Yarrowia lipolytica is a novel microbial chassis to upgrade renewable low-cost carbon
feedstocks to high-value commodity chemicals and natural products. In this work, we …

Overexpression of ATP sulfurylase in Indian mustard leads to increased selenate uptake, reduction, and tolerance

EAH Pilon-Smits, S Hwang, C Mel Lytle, Y Zhu… - Plant …, 1999 - academic.oup.com
In earlier studies, the assimilation of selenate by plants appeared to be limited by its reduction,
a step that is thought to be mediated by ATP sulfurylase. Here, the Arabidopsis APS1 …

Refactoring Ehrlich Pathway for High-Yield 2-Phenylethanol Production in Yarrowia lipolytica

Y Gu, J Ma, Y Zhu, P Xu - ACS Synthetic Biology, 2020 - ACS Publications
Efficient microbial synthesis of chemicals requires the coordinated supply of precursors and
cofactors to maintain cell growth and product formation. Substrates with different entry points …

[HTML][HTML] Engineered Bacillus subtilis for the de novo production of 2′-fucosyllactose

Q Zhang, Z Liu, H Xia, Z Huang, Y Zhu, L Xu, Y Liu… - Microbial Cell …, 2022 - Springer
Background The most abundant human milk oligosaccharide in breast milk, 2′-fucosyllactose
(2′-FL), has been approved as an additive to infant formula due to its multifarious …

An associative memory circuit based on physical memristors

M Guo, Y Zhu, R Liu, K Zhao, G Dou - Neurocomputing, 2022 - Elsevier
In this paper, a physical Sr 0.97 Ba 0.03 TiO 3 - x (SBT) memristor with the voltage threshold
characteristic was prepared. For characterizing the electrical characteristics of SBT …

Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil

S Balakrishna Pai, SH Liu, YL Zhu… - Antimicrobial agents …, 1996 - Am Soc Microbiol
2'-Fluoro-5-methyl-beta-L-arabinofuranosyl uracil (L-FMAU) was discovered to have potent
antiviral activity against hepatitis B virus (HBV). L-FMAU was more potent than its D-…

Structure−Activity Relationships of 1-(2-Deoxy-2-fluoro-β-l-arabino- furanosyl)pyrimidine Nucleosides as Anti-Hepatitis B Virus Agents

T Ma, SB Pai, YL Zhu, JS Lin… - Journal of medicinal …, 1996 - ACS Publications
Since 2‘-fluoro-5-methyl-β-l-arabinofuranosyluracil (l-FMAU) has been shown to be a potent
anti-HBV agent in vitro, it was of interest to study the structure−activity relationships of …

Hepatoma‐derived growth factor involved in the carcinogenesis of gastric epithelial cells through promotion of cell proliferation by Erk1/2 activation

…, Y Fang, H Wang, J Xu, J Ye, S Zheng, Y Zhu - Cancer …, 2008 - Wiley Online Library
Hepatoma‐derived growth factor (HDGF) is related to tumorigenesis and the development
of cancer; it is an independent factor associated with the prognosis of liver cancer, non‐small …

[HTML][HTML] DNA microarray analysis reveals that antibiotic resistance-gene diversity in human gut microbiota is age related

N Lu, Y Hu, L Zhu, X Yang, Y Yin, F Lei, Y Zhu, Q Du… - Scientific reports, 2014 - nature.com
The human gut is a reservoir for antibiotic resistance genes. In this report, we used a DNA
microarray chip covering 369 resistance types to investigate the relationship between …