Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show
that long-term treatment with metformin (0.1% w/w in diet) starting at middle age extends …

A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related
diseases in laboratory animals is greatly sought after. We and others have shown that …

Temperature programmed reduction (TPR) and hydrogen chemisorption combined with
reoxidation measurements were used to define the reducibility of supported cobalt catalysts. …

The long noncoding MALAT1 RNA is upregulated in cancer tissues and its elevated
expression is associated with hyper-proliferation, but the underlying mechanism is poorly …

Importance The aging of the population is associated with an increasing burden of fractures
worldwide. However, the epidemiological features of fractures in mainland China are not …

Background MicroRNAs (miRNAs) represent a class of small non-coding RNAs that control
gene expression by targeting mRNAs and triggering either translation repression or RNA …

The prevention or delay of the onset of age-related diseases prolongs survival and improves
quality of life while reducing the burden on the health care system. Activation of sirtuin 1 (…

Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However,
there are a number of emerging experimental variables that alter CR responses. We …

Emerging findings suggest that compromised cellular bioenergetics and DNA repair
contribute to the pathogenesis of Alzheimer’s disease (AD), but their role in disease-defining …

VEGF-B, a homolog of VEGF discovered a long time ago, has not been considered an important
target in antiangiogenic therapy. Instead, it has received little attention from the field. In …