Engineered fluorescent protein (FP) chimeras that modulate their fluorescence in response
to changes in calcium ion (Ca 2+ ) concentration are powerful tools for visualizing …

All-optical electrophysiology—spatially resolved simultaneous optical perturbation and
measurement of membrane voltage—would open new vistas in neuroscience research. We …

Realistic metrics and methods for testing household biomass cookstoves are required to
develop standards needed by international policy makers, donors, and investors. Application of …

Expansion microscopy (ExM) enables imaging of preserved specimens with nanoscale
precision on diffraction-limited instead of specialized super-resolution microscopes. ExM works …

Many biological investigations require 3D imaging of cells or tissues with nanoscale spatial
resolution. We recently discovered that preserved biological specimens can be physically …

Ferroptosis is recognized as a new form of regulated cell death which is initiated by severe
lipid peroxidation relying on reactive oxygen species (ROS) generation and iron overload. …

INTRODUCTION Neural circuits across the brain are composed of structures spanning seven
orders of magnitude in size that are assembled from thousands of distinct protein types. …

A technology that simultaneously records membrane potential from multiple neurons in
behaving animals will have a transformative effect on neuroscience research 1 , 2 . Genetically …

We have used protein engineering to expand the palette of genetically encoded calcium ion
(Ca 2+ ) indicators to include orange and improved red fluorescent variants, and validated …

Expansion microscopy (ExM), a method for improving the resolution of light microscopy by
physically expanding a specimen, has not been applied to clinical tissue samples. Here we …