Minocycline is a semi-synthetic tetracycline antibiotic that effectively crosses the blood–brain
barrier. Minocycline has been reported to have significant neuroprotective effects in models …

Background Neural stem cells (NSCs) have the ability to generate a variety of functional
neural cell types and have a high potential for neuronal cell regeneration and recovery. Thus, …

Background Dynamically altered microglia play an important role in the progression of
Alzheimer’s disease (AD). Here, we found a close association of the metabolic reconfiguration of …

Since glymphatic was proposed and meningeal lymphatic was discovered, MRI and even PET
were introduced to investigate brain parenchymal interstitial fluid (ISF), cerebrospinal fluid …

Drainage of parenchymal waste through the lymphatic system maintains brain homeostasis.
Age-related changes of glymphatic–lymphatic clearance lead to the accumulation beta-…

Age-related cognitive decline is associated with dysfunctional lymphatic drainage of cerebrospinal
fluid (CSF) through meningeal lymphatic vessels. In this study, intrathecal [ 64 Cu]Cu-…

Swedish double mutation (KM670/671NL) of amyloid precursor protein (Swe‐APP), a prevailing
cause of familial Alzheimer's disease (FAD), is known to increase in Aβ production both …

The AICD (APP intracellular Domain) and C31, caspase‐cleaved C‐terminal fragment of
APP, have been found in Alzheimer's disease (AD) patients' brains and have been reported to …

10.7554/eLife.11571.001 Neuroimaging has been used to examine developmental
changes of the brain. While PET studies revealed maturation-related changes, maturation of …

The pathological features of Alzheimer’s disease are senile plaques which are aggregates
of β-amyloid peptides and neurofibrillary tangles in the brain. Neurofibrillary tangles are …