User profiles for Yosef Gruenbaum
Yosef GruenbaumVerified email at mail.huji.ac.il Cited by 17876 |
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome
…, LB Gordon, Y Gruenbaum… - Proceedings of the …, 2004 - National Acad Sciences
Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disorder, commonly
caused by a point mutation in the lamin A gene that results in a protein lacking 50 aa near the …
caused by a point mutation in the lamin A gene that results in a protein lacking 50 aa near the …
The nuclear lamina comes of age
Y Gruenbaum, A Margalit, RD Goldman… - … reviews Molecular cell …, 2005 - nature.com
Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins,
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization, …
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization, …
Sequence specificity of methylation in higher plant DNA
Although plant DNA has a high content of 5-methylcytosine (5mC 1 ) very little is known
about the distribution of this modification. Many of these methylations are found in the …
about the distribution of this modification. Many of these methylations are found in the …
Nuclear lamins: building blocks of nuclear architecture
RD Goldman, Y Gruenbaum, RD Moir… - Genes & …, 2002 - genesdev.cshlp.org
Nuclear lamins were initially identified as the major components of the nuclear lamina, a
proteinaceous layer found at the interface between chromatin and the inner nuclear membrane (…
proteinaceous layer found at the interface between chromatin and the inner nuclear membrane (…
Substrate and sequence specificity of a eukaryotic DNA methylase
Y Gruenbaum, H Cedar, A Razin - Nature, 1982 - nature.com
In eukaryotic DNA, 50–90% of the dinucleotide sequence CG is methylated. Most methylated
sites are apparently placed at fixed locations in the genome and this methylation pattern is …
sites are apparently placed at fixed locations in the genome and this methylation pattern is …
Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation
Y Gruenbaum, R Foisner - Annual review of biochemistry, 2015 - annualreviews.org
Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm. …
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm. …
Essential Roles for Caenorhabditis elegans Lamin Gene in Nuclear Organization, Cell Cycle Progression, and Spatial Organization of Nuclear Pore Complexes
…, P Spann, K Weber, A Fire, Y Gruenbaum - Molecular biology of …, 2000 - Am Soc Cell Biol
Caenorhabditis elegans has a single lamin gene, designated lmn-1 (previously termed
CeLam-1). Antibodies raised against the lmn-1 product (Ce-lamin) detected a 64-kDa nuclear …
CeLam-1). Antibodies raised against the lmn-1 product (Ce-lamin) detected a 64-kDa nuclear …
[PDF][PDF] Methylation of CpG sequences in eukaryotic DNA
Y Gruenbaum, R Stein, H Cedar, A Razin - FEBS letters, 1981 - core.ac.uk
An understanding of the function of DNA methylation in eukaryotes will require a clearer,
more precise, knowledge of the distribution of methylated bases in the eukaryotic genome. …
more precise, knowledge of the distribution of methylated bases in the eukaryotic genome. …
Nuclear lamins: key regulators of nuclear structure and activities
…, R Barkan, E Meshorer, Y Gruenbaum - Journal of cellular …, 2009 - Wiley Online Library
… Yosef Gruenbaum… Yosef Gruenbaum … Yosef Gruenbaum…
Age-related changes of nuclear architecture in Caenorhabditis elegans
…, N Feinstein, A Mattout, Y Gruenbaum… - Proceedings of the …, 2005 - National Acad Sciences
Mutations in lamins cause premature aging syndromes in humans, including the Hutchinson–Gilford
Progeria Syndrome (HGPS) and Atypical Werner Syndrome. It has been shown that …
Progeria Syndrome (HGPS) and Atypical Werner Syndrome. It has been shown that …