Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disorder, commonly
caused by a point mutation in the lamin A gene that results in a protein lacking 50 aa near the …

Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins,
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization, …

Although plant DNA has a high content of 5-methylcytosine (5mC 1 ) very little is known
about the distribution of this modification. Many of these methylations are found in the …

Nuclear lamins were initially identified as the major components of the nuclear lamina, a
proteinaceous layer found at the interface between chromatin and the inner nuclear membrane (…

In eukaryotic DNA, 50–90% of the dinucleotide sequence CG is methylated. Most methylated
sites are apparently placed at fixed locations in the genome and this methylation pattern is …

Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm. …

Caenorhabditis elegans has a single lamin gene, designated lmn-1 (previously termed
CeLam-1). Antibodies raised against the lmn-1 product (Ce-lamin) detected a 64-kDa nuclear …

An understanding of the function of DNA methylation in eukaryotes will require a clearer,
more precise, knowledge of the distribution of methylated bases in the eukaryotic genome. …

… Yosef Gruenbaum… Yosef Gruenbaum … Yosef Gruenbaum…

Mutations in lamins cause premature aging syndromes in humans, including the Hutchinson–Gilford
Progeria Syndrome (HGPS) and Atypical Werner Syndrome. It has been shown that …