Stable inheritance of DNA methylation is critical for maintaining differentiated phenotypes in
multicellular organisms. We have recently identified dual mono-ubiquitylation of histone H3 (…

DNMT1 is an essential enzyme that maintains genomic DNA methylation, and its function is
regulated by mechanisms that are not yet fully understood. Here, we report the cryo-EM …

Ubiquitin-like with PHD and RING finger domain-containing protein 1 (UHRF1)-dependent
DNA methylation is essential for maintaining cell fate during cell proliferation. Developmental …

DNA ligase 1 (LIG1) is known as the major DNA ligase responsible for Okazaki fragment
joining. Recent studies have implicated LIG3 complexed with XRCC1 as an alternative player …

In tumor cell masses, the extracellular pH decreases below 6.5. The effect of external acidic
pH on the efficacy of 24 chemical compounds including molecular-targeted inhibitors and …

UHRF1-dependent ubiquitin signaling plays an integral role in the regulation of maintenance
DNA methylation. UHRF1 catalyzes transient dual mono-ubiquitylation of PAF15 (…

Animal cells undergo rapid rounding during mitosis, ensuring proper chromosome segregation,
during which an outward rounding force abruptly increases upon prometaphase entry …

Quantum-confined Stark effects on the electronic structure of a GaAs microcluster with 63.5-Å
(120-au) radius embedded in the Al x Ga 1− x As bulk crystal were investigated, within …

Epigenetic modifications such as DNA methylation and histone H3 lysine 27 methylation (H3K27me)
are repressive marks that silence gene expression. The M phase phosphoprotein (…

We propose an accurate and numerically stable coupled channel approach to molecular
vibration dynamics in diatomic molecule-surface interactions. This approach successfully …