User profiles for Yoshihiko Tashiro
 | Yoshihiko TashiroVerified email at juntendo.ac.jp Cited by 1160 |
Extent and instability of trimethylation of histone H3 lysine increases with degree of malignancy and methionine addiction
…, Q Han, K Hamada, Y Tashiro… - Cancer Genomics & …, 2022 - cgp.iiarjournals.org
Background/Aim: Methionine addiction is a fundamental and general hallmark of cancer,
termed the Hoffman effect. Methionine addiction is due to excessive use of and dependence on …
termed the Hoffman effect. Methionine addiction is due to excessive use of and dependence on …
Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice
Y Tashiro, C Nishida, K Sato-Kusubata… - Blood, The Journal …, 2012 - ashpublications.org
Plasminogen activator inhibitor-1 (PAI-1), an endogenous inhibitor of a major fibrinolytic factor,
tissue-type plasminogen activator, can both promote and inhibit angiogenesis. However, …
tissue-type plasminogen activator, can both promote and inhibit angiogenesis. However, …
Ultrasound-guided preoperative positive percutaneous indocyanine green fluorescence staining for laparoscopic anatomical liver resection
…, T Kusano, K Matsuda, Y Tashiro… - Journal of the …, 2020 - journals.lww.com
METHODS Patients Between January 2017 and May 2019, laparoscopic ALR with ICG
fluorescence imaging was performed in 14 patients at the Department of Surgery, Showa …
fluorescence imaging was performed in 14 patients at the Department of Surgery, Showa …
Plasminogen activator inhibitor‐1 regulates macrophage‐dependent postoperative adhesion by enhancing EGF‐HER1 signaling in mice
Adhesive small bowel obstruction remains a common problem for surgeons. After surgery,
platelet aggregation contributes to coagulation cascade and fibrin clot formation. With clotting, …
platelet aggregation contributes to coagulation cascade and fibrin clot formation. With clotting, …
Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse …
Methionine addiction is a fundamental and general hallmark of cancer. Gene expression
analysis showed that methionine restriction (MR) of methionine-addicted cancer cells increases …
analysis showed that methionine restriction (MR) of methionine-addicted cancer cells increases …
Pharmacological targeting of plasmin prevents lethality in a murine model of macrophage activation syndrome
H Shimazu, S Munakata, Y Tashiro… - Blood, The Journal …, 2017 - ashpublications.org
Macrophage activation syndrome (MAS) is a life-threatening disorder characterized by a
cytokine storm and multiorgan dysfunction due to excessive immune activation. Although …
cytokine storm and multiorgan dysfunction due to excessive immune activation. Although …
Inhibition of plasmin protects against colitis in mice by suppressing matrix metalloproteinase 9–mediated cytokine release from myeloid cells
S Munakata, Y Tashiro, C Nishida, A Sato… - Gastroenterology, 2015 - Elsevier
Background & Aims Activated proteases such as plasmin and matrix metalloproteinases (MMPs)
are activated in intestinal tissues of patients with active inflammatory bowel diseases. …
are activated in intestinal tissues of patients with active inflammatory bowel diseases. …
MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells
C Nishida, K Kusubata, Y Tashiro, I Gritli… - Blood, The Journal …, 2012 - ashpublications.org
HSC fate decisions are regulated by cell-intrinsic and cell-extrinsic cues. The latter cues are
derived from the BM niche. Membrane-type 1 matrix metalloproteinase (MT1-MMP), which is …
derived from the BM niche. Membrane-type 1 matrix metalloproteinase (MT1-MMP), which is …
Pathological validity of using near-infrared fluorescence imaging for securing surgical margins during liver resection
Y Tashiro, T Aoki, T Hirai, T Koizumi… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: This study investigated the use of near-infrared fluorescent imaging for
securing safe margins during liver resection. Patients and Methods: This study included 125 …
securing safe margins during liver resection. Patients and Methods: This study included 125 …
Over-methylation of histone H3 lysines is a common molecular change among the three major types of soft-tissue sarcoma in patient-derived xenograft (PDX) mouse …
Background/Aim: Sarcomas are considered a heterogeneous disease with incomplete
understanding of its molecular basis. In the present study, to further understand general …
understanding of its molecular basis. In the present study, to further understand general …