Heart failure is the major cause of death for muscular dystrophy patients, however, the
molecular pathomechanism remains unknown. Here, we show the detailed molecular …

We developed a mechano-cell model incorporating a cell membrane, a nuclear envelope,
and actin filaments to simulate the mechanical behavior of a cell during tensile tests. The …

A cardioprotective response that alters ventricular contractility or promotes cardiomyocyte
enlargement occurs with increased workload in conditions such as hypertension. When that …

Aims Although increased Na + /Ca 2+ exchanger 1 (NCX1) expression is observed during
heart failure (HF), the pathological role of NCX1 during the progression of HF remains unclear…

The role of actin filaments and microtubules in 3D cell morphology was investigated using
confocal laser scanning microscopy and image analysis based on a regiongrowing method. …

The heart has a dynamic compensatory mechanism for haemodynamic stress. However, the
molecular details of how mechanical forces are transduced in the heart are unclear. Here …

Transfer RNAs (tRNAs) contain a wide variety of posttranscriptional modifications that are
important for accurate decoding. Mammalian mitochondrial tRNAs (mt-tRNAs) are modified by …

The ratio of type III to type I collagen is important for properly maintaining functions of organs
and cells. We propose a method to quantify the ratio of type III to total (type I + III) collagen (λ …

Fetal cardiomyocytes actively proliferate to form the primitive heart in utero in mammals, but
they stop dividing shortly after birth. The identification of essential molecules maintaining this …

The Na + /Ca 2+ exchanger 1 (NCX1) is an essential Ca 2+ efflux system in cardiomyocytes.
Although NCX1 is distributed throughout the sarcolemma, a subpopulation of NCX1 is …