ColabFold offers accelerated prediction of protein structures and complexes by combining
the fast homology search of MMseqs2 with AlphaFold2 or RoseTTAFold. ColabFold’s 40−60-…

The extracellular pH is a vital regulator of various biological processes in plants. However,
how plants perceive extracellular pH remains obscure. Here, we report that plant cell-surface …

Antibiotic resistance is increasingly seen as a serious problem that threatens public health
and erodes our capacity to effectively combat disease. So-called non-iron metalloporhyrins …

Self-incompatibility (SI) is a breeding system that promotes cross-fertilization. In Brassica,
pollen rejection is induced by a haplotype-specific interaction between pistil determinant SRK (…

We propose a new iterative screening contest method to identify target protein inhibitors.
After conducting a compound screening contest in 2014, we report results acquired from a …

Conventional computerbased methods for identifying antifungal peptides (AFPs) are
primarily based on large amounts of task-specific knowledge in feature extraction. This paper …

Cosolvent molecular dynamics (CMD) simulations involve an MD simulation of a protein in
the presence of explicit water molecules mixed with cosolvent molecules to perform hotspot …

Prenyl pyrophosphate methyltransferases enhance the structural diversity of terpenoids.
However, the molecular basis of their catalytic mechanisms is poorly understood. In this study, …

Antifreeze proteins (AFPs) are proteins that protect cellular fluids and body fluids from freezing
by inhibiting the nucleation and growth of ice crystals and preventing ice recrystallization, …

p-Hydroxybenzoate hydroxylase (PHBH) is a flavoprotein monooxygenase that catalyzes the
hydroxylation of p-hydroxybenzoate (p-OHB) to 3,4-dihydroxybenzoate (3,4-DOHB). PHBH …