Partial reprogramming by expression of reprogramming factors (Oct4, Sox2, Klf4 and c-Myc)
for short periods of time restores a youthful epigenetic signature to aging cells and extends …

Ravulizumab is a long-acting C5 inhibitor engineered from eculizumab with increased
elimination half-life, allowing an extended dosing interval from two to eight weeks. Here we …

Vancomycin is a widely prescribed antibiotic, but the exact nature of vancomycin-associated
nephrotoxicity is unclear, in particular when considering the frequent coadministration of …

Circulating levels of soluble forms of urokinase-type plasminogen activator receptor (suPAR)
are generally elevated in sera from children and adults with FSGS compared with levels in …

Introduction Atypical hemolytic uremic syndrome (aHUS) is a rare, complex, multisystem
disease of dysregulated complement activity, characterized by progressive thrombotic …

Dear Sirs, Epidemiological data regarding the frequency of the different causes of coma and
their evolution over time in the ICU are scarce [1–4]. In the 1970s, Plum and Posner [2] …

Introduction Vancomycin nephrotoxicity is frequent and may be due to drug-induced acute
tubular necrosis (ATN) or tubulointerstitial nephritis (TIN). Vancomycin-associated tubular cast …

Infrared (IR) spectromicroscopy allows chemical mapping of a kidney biopsy. It is particularly
interesting for chemical speciation of abnormal tubular deposits and calcification. In 2017, …

Absent in melanoma-2 (AIM2) is an inflammasome-forming innate immune sensor for
dsDNA but also exhibits inflammasome-independent functions such as restricting cellular …

Severe hypertension revealing a CKD is a common situation in adult nephrology. Despite in-depth
etiologic investigations, uncontrolled hypertension is often retained as thefinal cause …