[HTML][HTML] Transcription and Translation Products of the Cytolysin Gene psm-mec on the Mobile Genetic Element SCCmec Regulate Staphylococcus aureus Virulence
C Kaito, Y Saito, G Nagano, M Ikuo, Y Omae… - PLoS …, 2011 - journals.plos.org
The F region downstream of the mecI gene in the SCCmec element in hospital-associated
methicillin-resistant Staphylococcus aureus (HA-MRSA) contains two bidirectionally …
methicillin-resistant Staphylococcus aureus (HA-MRSA) contains two bidirectionally …
[HTML][HTML] Mobile Genetic Element SCCmec-encoded psm-mec RNA Suppresses Translation of agrA and Attenuates MRSA Virulence
C Kaito, Y Saito, M Ikuo, Y Omae, H Mao… - PLoS …, 2013 - journals.plos.org
Community acquired-methicillin resistant Staphylococcus aureus (CA-MRSA) is a socially
problematic pathogen that infects healthy individuals, causing severe disease. CA-MRSA is …
problematic pathogen that infects healthy individuals, causing severe disease. CA-MRSA is …
[HTML][HTML] HLA-A* 11: 01: 01: 01, HLA-C* 12: 02: 02: 01-HLA-B* 52: 01: 02: 02, age and sex are associated with severity of Japanese COVID-19 with respiratory failure
SS Khor, Y Omae, N Nishida, M Sugiyama… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing
coronavirus disease 2019 (COVID-19) was announced as an outbreak by the World Health …
coronavirus disease 2019 (COVID-19) was announced as an outbreak by the World Health …
Strong association of the HLA-DR/DQ locus with childhood steroid-sensitive nephrotic syndrome in the Japanese population
…, Y Hitomi, A Shono, SS Khor, Y Omae… - Journal of the …, 2018 - journals.lww.com
Background Nephrotic syndrome is the most common cause of chronic glomerular disease
in children. Most of these patients develop steroid-sensitive nephrotic syndrome (SSNS), but …
in children. Most of these patients develop steroid-sensitive nephrotic syndrome (SSNS), but …
[HTML][HTML] Genome-wide host-pathogen analyses reveal genetic interaction points in tuberculosis disease
…, PJ Gomez-Gonzalez, N Andreu, Y Omae… - Nature …, 2023 - nature.com
The genetics underlying tuberculosis (TB) pathophysiology are poorly understood. Human
genome-wide association studies have failed so far to reveal reproducible susceptibility loci, …
genome-wide association studies have failed so far to reveal reproducible susceptibility loci, …
[HTML][HTML] Pathogen lineage-based genome-wide association study identified CD53 as susceptible locus in tuberculosis
Y Omae, L Toyo-Oka, H Yanai, S Nedsuwan… - Journal of Human …, 2017 - nature.com
Tuberculosis (TB) is known to be affected by host genetic factors. We reported a specific genetic
risk factor through a genome-wide association study (GWAS) that focused on young age …
risk factor through a genome-wide association study (GWAS) that focused on young age …
Identification of region-specific gene isoforms in the human brain using long-read transcriptome sequencing
M Shimada, Y Omae, A Kakita, R Gabdulkhaev… - Science …, 2024 - science.org
In neurological and neuropsychiatric diseases, different brain regions are affected, and
differences in gene expression patterns could potentially explain this mechanism. However, …
differences in gene expression patterns could potentially explain this mechanism. However, …
[HTML][HTML] Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis
Y Kawai, Y Watanabe, Y Omae, R Miyahara… - Plos …, 2023 - journals.plos.org
The Japanese archipelago is a terminal location for human migration, and the contemporary
Japanese people represent a unique population whose genomic diversity has been …
Japanese people represent a unique population whose genomic diversity has been …
Genomewide Association Study Confirming the Association of NAT2 with Susceptibility to Antituberculosis Drug-Induced Liver Injury in Thai Patients
…, M Maneerat, K Fukunaga, Y Omae… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Antituberculosis drug-induced liver injury (ATDILI) is a common side effect leading to tuberculosis
(TB) treatment disruption. The mechanism of the disease remains poorly understood. …
(TB) treatment disruption. The mechanism of the disease remains poorly understood. …
[HTML][HTML] A Novel Gene, fudoh, in the SCCmec Region Suppresses the Colony Spreading Ability and Virulence of Staphylococcus aureus
C Kaito, Y Omae, Y Matsumoto, M Nagata… - PLoS …, 2008 - journals.plos.org
Staphylococcus aureus colonies can spread on soft agar plates. We compared colony
spreading of clinically isolated methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. …
spreading of clinically isolated methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. …