[PDF][PDF] Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma

YS Lee, JW Lee, JW Jang, XZ Chi, JH Kim, YH Li… - Cancer cell, 2013 - cell.com
Targeted inactivation of Runx3 in mouse lung induced mucinous and nonmucinous adenomas
and markedly shortened latency of adenocarcinoma formation induced by oncogenic K-…

[HTML][HTML] Lung cancer staging and associated genetic and epigenetic events

D Kim, YS Lee, DH Kim, SC Bae - Molecules and cells, 2020 - Elsevier
The first step in treating lung cancer is to establish the stage of the disease, which in turn
determines the treatment options and prognosis of the patient. Many factors are involved in lung …

[HTML][HTML] Role of RUNX3 in restriction point regulation

JW Lee, YS Lee, MK Kim, XZ Chi, D Kim, SC Bae - Cells, 2023 - mdpi.com
A cell cycle is a series of events that takes place in a cell as it grows and divides. At the G 1
phase of cell cycle, cells monitor their cumulative exposure to specific signals and make the …

[HTML][HTML] RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point

JW Lee, DM Kim, JW Jang, TG Park, SH Song… - Nature …, 2019 - nature.com
The cellular decision regarding whether to undergo proliferation or death is made at the
restriction (R)-point, which is disrupted in nearly all tumors. The identity of the molecular …

[HTML][HTML] Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm

…, ETH Hong, YS Lee, JH Kim, JW Jang, YH Li… - Journal of biological …, 2010 - ASBMB
RUNX3 is a transcription factor that functions as a tumor suppressor. In some cancers, RUNX3
expression is down-regulated, usually due to promoter hypermethylation. Recently, it was …

Jab1/CSN5 induces the cytoplasmic localization and degradation of RUNX3

…, YS Lee, YH Li, YM Goh, XZ Chi, KS Lee… - Journal of cellular …, 2009 - Wiley Online Library
Runt‐related (RUNX) transcription factors play pivotal roles in neoplastic development and
have tissue‐specific developmental roles in hematopoiesis (RUNX1), osteogenesis (RUNX2)…

Runx3 is a crucial regulator of alveolar differentiation and lung tumorigenesis in mice

JM Lee, JO Shin, KW Cho, A Hosoya, SW Cho, YS Lee… - Differentiation, 2011 - Elsevier
The runt-domain transcription factor Runx3 plays crucial roles during development such as
regulating gene expression. It has been shown that Runx3 is involved in neurogenesis, …

[HTML][HTML] Runx3 Restoration Regresses K-Ras-Activated Mouse Lung Cancers and Inhibits Recurrence

JY Lee, JW Lee, TG Park, SH Han, SY Yoo, KM Jung… - Cells, 2023 - mdpi.com
Oncogenic K-RAS mutations occur in approximately 25% of human lung cancers and are
most frequently found in codon 12 (G12C, G12V, and G12D). Mutated K-RAS inhibitors have …

[HTML][HTML] The TGFβ→ TAK1→ LATS→ YAP1 Pathway Regulates the Spatiotemporal Dynamics of YAP1

MK Kim, SH Han, TG Park, SH Song, JY Lee, YS Lee… - Molecules and …, 2023 - Elsevier
The Hippo kinase cascade functions as a central hub that relays input from the “outside world”
of the cell and translates it into specific cellular responses by regulating the activity of Yes-…

Phosphorylation of the gastric tumor suppressor RUNX3 following H. pylori infection results in its localization to the cytoplasm

…, YM Goh, BC Oh, YS Lee, OJ Lee… - Journal of Cellular …, 2012 - Wiley Online Library
As H. pylori infection progresses, intestinal metaplasia (IM), a key event in gastric carcinogenesis,
develops in the stomach. The mechanism by which H. pylori infection causes the trans‐…