[HTML][HTML] Automatic morphological subtyping reveals new roles of caspases in mitochondrial dynamics

…, CC Lin, YJ Chen, LS Kao, YC Liu… - PLoS computational …, 2011 - journals.plos.org
Morphological dynamics of mitochondria is associated with key cellular processes related to
aging and neuronal degenerative diseases, but the lack of standard quantification of …

Autocrine stimulation by insulin-like growth factor I is involved in the growth, tumorigenicity and chemoresistance of human esophageal carcinoma cells

YC Liu, CM Leu, FH Wong, WS Fong, SC Chen… - Journal of biomedical …, 2002 - Springer
Insulin-like growth factor I (IGF-I) receptor (IGF-IR)-mediated signals are known to be
involved in cell growth and transformation and prevention of apoptosis. In this study, we …

Requirement of MMP‐3 in anchorage‐independent growth of oral squamous cell carcinomas

SY Liu, YC Liu, WT Huang, GC Huang… - Journal of oral …, 2007 - Wiley Online Library
Background: Matrix metalloproteinase‐3 (MMP‐3) is expressed in various carcinomas;
however, its function is not clearly established. This study was to assess its possible role in oral …

Arecoline-mediated inhibition of AMP-activated protein kinase through reactive oxygen species is required for apoptosis induction

CY Yen, MH Lin, SY Liu, WF Chiang, WF Hsieh… - Oral Oncology, 2011 - Elsevier
Arecoline is the major alkaloid of areca nut (AN) and known to induce reactive oxygen species
(ROS) production and apoptosis. The metabolic sensor AMP-activated protein kinase (…

The synergistic cytotoxicity of cisplatin and taxol in killing oral squamous cell carcinoma

…, SY Liu, MH Lin, YY Kuo, YC Liu - Japanese Journal of …, 2004 - academic.oup.com
Background: Platinum, 5-fluorouracil (5-FU) and taxanes are commonly used in
chemotherapeutic modalities of various carcinomas. However, taxanes are rarely used in patients …

Autophagy induction by the 30–100 kDa fraction of areca nut in both normal and malignant cells through reactive oxygen species

…, YC Cheng, TC Chen, KC Hsu, PY Lina, SY Liu, YC Liu - Oral oncology, 2010 - Elsevier
Areca nut (AN) is an addictive carcinogen used by about 200–600 million people worldwide.
Some AN components are shown to induce apoptosis; however, we previously …

Functional role of matrix metalloproteinase-28 in the oral squamous cell carcinoma

MH Lin, SY Liu, HJ Su, YC Liu - Oral oncology, 2006 - Elsevier
The newly identified MMP-28 has been shown to be expressed in several types of carcinomas,
however, its functional role in transformation events is unknown. This study was to assess …

Long‐term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity

CY Yen, WF Chiang, SY Liu, PC Cheng… - Journal of oral …, 2014 - Wiley Online Library
Background We previously demonstrated the autophagy‐inducing activity in the crude
extract of areca nut ( ANE ) and its 30–100 kDa fraction ( ANE 30–100 K). This study aimed to …

Platelet-derived growth factor is an autocrine stimulator for the growth and survival of human esophageal carcinoma cell lines

YC Liu, SC Chen, C Chang, CM Leu, CP Hu - Experimental cell research, 1996 - Elsevier
Platelet-derived growth factors (PDGF) are important mitogens for mesenchyme-derived
cells. Neither PDGF nor PDGF receptors (PDGFR) are expressed in epithelial cells under …

Up-regulation of matrix metalloproteinase-8 by betel quid extract and arecoline and its role in 2D motility

SY Liu, YC Liu, WT Huang, GC Huang, TC Chen… - Oral oncology, 2007 - Elsevier
Betel quid (BQ) and matrix metalloproteinase-8 (MMP-8) play roles in oral diseases. Here,
we analyzed the regulation of MMP-8 by BQ and its effect on cell migration. We found that BQ …