The primary cilium, a hair-like extension from a cell's surface, acts as a sensory organelle to
receive signals that regulate cellular behavior and physiology. Like most mammalian cells, …

The primary cilium, a sensory appendage that is present in most mammalian cells, plays critical
roles in signaling pathways and cell cycle progression. Mutations that affect the structure …

Whether the brain tumor medulloblastoma originates from stem cells or restricted progenitor
cells is unclear. To investigate this, we activated oncogenic Hedgehog (Hh) signaling in …

Neural stem cells that continue to produce neurons are retained in the adult hippocampal
dentate gyrus. The mechanisms by which embryonic neural progenitors expand and transform …

Recent work has shown that primary cilia are essential for Hedgehog (Hh) signaling during
mammalian development 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 . It is also known that aberrant Hh …

In mammals, motile cilia cover many organs, such as fallopian tubes, respiratory tracts and
brain ventricles. The development and function of these organs critically depend on efficient …

Multiciliated epithelial cells, called ependymal cells, line the ventricles in the adult brain.
Most ependymal cells are born prenatally and are derived from radial glia. Ependymal cells …

Background: Intraflagellar transport (IFT) uses kinesin II to carry a multiprotein particle to the
tips of eukaryotic cilia and flagella and a nonaxonemal dynein to return it to the cell body. …

Sonic Hedgehog (SHH) signaling has been most widely known for its role in specifying region
and cell-type identity during embryonic morphogenesis. This mini-review accompanies a …

The unique mental abilities of humans are rooted in the immensely expanded and folded
neocortex, which reflects the expansion of neural progenitors, especially basal progenitors …