User profiles for Youxing Jiang

Youxing Jiang

professor of Physiology, UT Southwestern Medical Center
Verified email at utsouthwestern.edu
Cited by 12222

X-ray structure of a voltage-dependent K+ channel

Y Jiang, A Lee, J Chen, V Ruta, M Cadene, BT Chait… - Nature, 2003 - nature.com
Voltage-dependent K + channels are members of the family of voltage-dependent cation (K
+ , Na + and Ca 2+ ) channels that open and allow ion conduction in response to changes in …

Atomic structure of a Na+- and K+-conducting channel

N Shi, S Ye, A Alam, L Chen, Y Jiang - Nature, 2006 - nature.com
Ion selectivity is one of the basic properties that define an ion channel. Most tetrameric
cation channels, which include the K + , Ca 2+ , Na + and cyclic nucleotide-gated channels, …

Crystal structure and mechanism of a calcium-gated potassium channel

Y Jiang, A Lee, J Chen, M Cadene, BT Chait… - Nature, 2002 - nature.com
Ion channels exhibit two essential biophysical properties; that is, selective ion conduction,
and the ability to gate-open in response to an appropriate stimulus. Two general categories of …

The open pore conformation of potassium channels

Y Jiang, A Lee, J Chen, M Cadene, BT Chait… - Nature, 2002 - nature.com
Living cells regulate the activity of their ion channels through a process known as gating. To
open the pore, protein conformational changes must occur within a channel's membrane-…

The principle of gating charge movement in a voltage-dependent K+ channel

Y Jiang, V Ruta, J Chen, A Lee, R MacKinnon - Nature, 2003 - nature.com
The steep dependence of channel opening on membrane voltage allows voltage-dependent
K + channels to turn on almost like a switch. Opening is driven by the movement of gating …

Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger

J Liao, H Li, W Zeng, DB Sauer, R Belmares, Y Jiang - Science, 2012 - science.org
Sodium/calcium (Na + /Ca 2+ ) exchangers (NCX) are membrane transporters that play an
essential role in maintaining the homeostasis of cytosolic Ca 2+ for cell signaling. We …

[HTML][HTML] Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel

Y Jiang, A Pico, M Cadene, BT Chait, R MacKinnon - Neuron, 2001 - cell.com
The intracellular C-terminal domain structure of a six-transmembrane K + channel from
Escherichia coli has been solved by X-ray crystallography at 2.4 Ĺ resolution. The structure is …

Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel

Y Wu, Y Yang, S Ye, Y Jiang - Nature, 2010 - nature.com
Large-conductance Ca 2+ -gated K + (BK) channels are essential for many biological processes
such as smooth muscle contraction and neurotransmitter release 1 , 2 , 3 , 4 . This group …

Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana

…, C Lee, L Chen, Y Yang, C Cang, D Ren, Y Jiang - Nature, 2016 - nature.com
Two-pore channels (TPCs) contain two copies of a Shaker-like six-transmembrane (6-TM)
domain in each subunit and are ubiquitously expressed in both animals and plants as …

Functional analysis of an archaebacterial voltage-dependent K+ channel

V Ruta, Y Jiang, A Lee, J Chen, R MacKinnon - Nature, 2003 - nature.com
All living organisms use ion channels to regulate the transport of ions across cellular
membranes 1 . Certain ion channels are classed as voltage-dependent because they have a …