User profiles for Youxing Jiang
Youxing Jiangprofessor of Physiology, UT Southwestern Medical Center Verified email at utsouthwestern.edu Cited by 12222 |
X-ray structure of a voltage-dependent K+ channel
Voltage-dependent K + channels are members of the family of voltage-dependent cation (K
+ , Na + and Ca 2+ ) channels that open and allow ion conduction in response to changes in …
+ , Na + and Ca 2+ ) channels that open and allow ion conduction in response to changes in …
Atomic structure of a Na+- and K+-conducting channel
Ion selectivity is one of the basic properties that define an ion channel. Most tetrameric
cation channels, which include the K + , Ca 2+ , Na + and cyclic nucleotide-gated channels, …
cation channels, which include the K + , Ca 2+ , Na + and cyclic nucleotide-gated channels, …
Crystal structure and mechanism of a calcium-gated potassium channel
Ion channels exhibit two essential biophysical properties; that is, selective ion conduction,
and the ability to gate-open in response to an appropriate stimulus. Two general categories of …
and the ability to gate-open in response to an appropriate stimulus. Two general categories of …
The open pore conformation of potassium channels
Living cells regulate the activity of their ion channels through a process known as gating. To
open the pore, protein conformational changes must occur within a channel's membrane-…
open the pore, protein conformational changes must occur within a channel's membrane-…
The principle of gating charge movement in a voltage-dependent K+ channel
The steep dependence of channel opening on membrane voltage allows voltage-dependent
K + channels to turn on almost like a switch. Opening is driven by the movement of gating …
K + channels to turn on almost like a switch. Opening is driven by the movement of gating …
Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger
Sodium/calcium (Na + /Ca 2+ ) exchangers (NCX) are membrane transporters that play an
essential role in maintaining the homeostasis of cytosolic Ca 2+ for cell signaling. We …
essential role in maintaining the homeostasis of cytosolic Ca 2+ for cell signaling. We …
[HTML][HTML] Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel
The intracellular C-terminal domain structure of a six-transmembrane K + channel from
Escherichia coli has been solved by X-ray crystallography at 2.4 Ĺ resolution. The structure is …
Escherichia coli has been solved by X-ray crystallography at 2.4 Ĺ resolution. The structure is …
Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel
Y Wu, Y Yang, S Ye, Y Jiang - Nature, 2010 - nature.com
Large-conductance Ca 2+ -gated K + (BK) channels are essential for many biological processes
such as smooth muscle contraction and neurotransmitter release 1 , 2 , 3 , 4 . This group …
such as smooth muscle contraction and neurotransmitter release 1 , 2 , 3 , 4 . This group …
Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana
Two-pore channels (TPCs) contain two copies of a Shaker-like six-transmembrane (6-TM)
domain in each subunit and are ubiquitously expressed in both animals and plants as …
domain in each subunit and are ubiquitously expressed in both animals and plants as …
Functional analysis of an archaebacterial voltage-dependent K+ channel
All living organisms use ion channels to regulate the transport of ions across cellular
membranes 1 . Certain ion channels are classed as voltage-dependent because they have a …
membranes 1 . Certain ion channels are classed as voltage-dependent because they have a …