One of the unique characteristics of cellular signaling pathways is that a common signaling
pathway can selectively regulate multiple cellular functions of a hormone; however, this …

Insulin governs systemic glucose metabolism, including glycolysis, gluconeogenesis and
glycogenesis, through temporal change and absolute concentration. However, how insulin‐…

In cellular signal transduction, the information in an external stimulus is encoded in temporal
patterns in the activities of signaling molecules; for example, pulses of a stimulus may …

Cellular homeostasis is regulated by signals through multiple molecular networks that
include protein phosphorylation and metabolites. However, where and when the signal flows …

To measure the activity of neurons using whole-brain activity imaging, precise detection of
each neuron or its nucleus is required. In the head region of the nematode C. elegans, the …

Background Annotation of cell identity is an essential process in neuroscience that allows
comparison of cells, including that of neural activities across different animals. In …

Tracking many cells in time-lapse 3D image sequences is an important challenging task of
bioimage informatics. Motivated by a study of brain-wide 4D imaging of neural activity in C. …

Animals demonstrate flexible behaviors through associative learning based on their
experiences. Deciphering the neural mechanisms for sensing and integrating multiple types of …

Animals navigate their environment by manipulating their movements and adjusting their
trajectory which requires a sophisticated integration of sensory data with their current motor …

Motivation: Automated fluorescence microscopes produce massive amounts of images
observing cells, often in four dimensions of space and time. This study addresses two tasks of …