Neurons containing the neuropeptide orexin (hypocretin) are located exclusively in the lateral
hypothalamus and send axons to numerous regions throughout the central nervous system…

Leptin is an adipose-derived hormone that regulates a wide variety of physiological processes,
including feeding behavior, metabolic rate, sympathetic nerve activity, reproduction, and …

In search of metabolically regulated secreted proteins, we conducted a microarray study
comparing gene expression in major metabolic tissues of fed and fasted ob/ob mice and C57BL/…

The molecular mechanisms that direct the development of TCRαβ + CD8αα + intestinal
intraepithelial lymphocytes (IELs) are not thoroughly understood. Here we show that transforming …

How CD4-CD8 differentiation is maintained in mature T cells is largely unknown. The present
study has examined the role in this process of the zinc finger protein Zbtb7b, a critical …

FFA1 (GPR40) and GPR120 are G-protein-coupled receptors activated by long-chain fatty
acids. FFA1 is expressed in pancreatic β-cells, where it regulates glucose-dependent insulin …

The transcription factor ThPOK promotes CD4 + T cell differentiation in the thymus. Here,
using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains …

Pharmacological treatment of recombinant growth differentiation factor 15 (GDF15) proteins
reduces body weight in obese rodents and primates. Paradoxically, circulating GDF15 levels …

The proper choice of the CD4-helper or CD8-cytotoxic lineages by developing T cells is crucial
for the generation of an antigen-responsive and functionally fit T cell repertoire. Here we …

The transcription factor Ets1 contributes to the differentiation of CD8 lineage cells in the
thymus, but how it does so is not understood. In this study, we demonstrate that Ets1 is required …