The induction of pluripotency or trans-differentiation of one cell type to another can be
accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a …

Recent transcriptome analysis indicates that > 90% of human genes undergo alternative
splicing, underscoring the contribution of differential RNA processing to diverse proteomes in …

Spermatogenesis in mammals is characterized by two waves of piRNA expression: one
corresponds to classic piRNAs responsible for silencing retrotransponsons and the second …

Parkinson’s disease is characterized by loss of dopamine neurons in the substantia nigra 1
. Similar to other major neurodegenerative disorders, there are no disease-modifying …

MicroRNAs are well known to mediate translational repression and mRNA degradation in
the cytoplasm. Various microRNAs have also been detected in membrane-compartmentalized …

Highly structured RNA molecules usually interact with each other, and associate with various
RNA-binding proteins, to regulate critical biological processes. However, RNA structures …

Picornaviruses have evolved to hijack host cellular machinery, including the autophagic
pathway. However, the mechanisms remain largely unclear. We use coxsackievirus B3 (CVB3) …

The piRNA machinery is known for its role in mediating epigenetic silencing of transposons.
Recent studies suggest that this function also involves piRNA-guided cleavage of …

Reconstructing the sequence of circular RNAs (circRNAs) from short RNA sequencing reads
has proved challenging given the similarity of circRNAs and their corresponding linear …

Neurodegenerative diseases can occur so early as to affect neurodevelopment. From a
cohort of more than 2,000 consanguineous families with childhood neurological disease, we …