A review of three-dimensional in vitro tissue models for drug discovery and transport studies
NT Elliott, FAN Yuan - Journal of pharmaceutical sciences, 2011 - Elsevier
The use of animal models in drug discovery studies presents issues with feasibility and
ethical concerns. To address these limitations, in vitro tissue models have been developed to …
ethical concerns. To address these limitations, in vitro tissue models have been developed to …
Quantitative angiogenesis assays: progress and problems
The tumor vasculature consists of vessels from the preexisting network of the host vasculature
and vessels resulting from the angiogenic response of the host vessels to cancer and …
and vessels resulting from the angiogenic response of the host vessels to cancer and …
Rational design of electrochemiluminescent devices
X Ma, W Gao, F Du, F Yuan, J Yu, Y Guan… - Accounts of Chemical …, 2021 - ACS Publications
Conspectus Electrochemiluminescence (ECL) is a light-emitting process which combines
the intriguing merits of both electrochemical and chemiluminescent methods. It is an …
the intriguing merits of both electrochemical and chemiluminescent methods. It is an …
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment
SK Hobbs, WL Monsky, F Yuan… - Proceedings of the …, 1998 - National Acad Sciences
Novel anti-neoplastic agents such as gene targeting vectors and encapsulated carriers are
quite large (approximately 100–300 nm in diameter). An understanding of the functional size …
quite large (approximately 100–300 nm in diameter). An understanding of the functional size …
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size
Molecular size is one of the key determinants of transvascular transport of therapeutic agents
in tumors. However, there are no data in the literature on the molecular size dependence of …
in tumors. However, there are no data in the literature on the molecular size dependence of …
Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
The partial pressure of oxygen (pO 2 ) and pH play critical roles in tumor biology and therapy.
We report here the first combined, high-resolution (≤10 μm) measurements of interstitial …
We report here the first combined, high-resolution (≤10 μm) measurements of interstitial …
Mirovascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft
Microvascular permeability and interstitial penetration of sterically stabilized liposomes in both
normal sc tissue and human colon adenocarcinoma LS174T xenograft were quantified by …
normal sc tissue and human colon adenocarcinoma LS174T xenograft were quantified by …
Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers
…, CR Michelich, MW Dewhirst, F Yuan… - Journal of the …, 2006 - academic.oup.com
Background: Delivery of anticancer therapeutic agents to solid tumors is problematic.
Macromolecular drug carriers are an attractive alternative drug delivery method because they …
Macromolecular drug carriers are an attractive alternative drug delivery method because they …
Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular …
The hyperpermeability of tumor vessels to macromolecules, compared with normal vessels,
is presumably due to vascular endothelial growth factor/vascular permeability factor (VEGF/…
is presumably due to vascular endothelial growth factor/vascular permeability factor (VEGF/…
Distributed event-triggered control of multi-agent systems with combinational measurements
This paper studies the distributed rendezvous problem of multi-agent systems with novel
event-triggered controllers. We have proposed a combinational measurement approach to …
event-triggered controllers. We have proposed a combinational measurement approach to …