Abstract Treatment with immune checkpoint blockade (ICB) has revolutionized cancer therapy.
Until now, predictive biomarkers 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 – 10 and strategies to augment …

Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …

Background Bisulfite sequencing is a powerful technique to study DNA cytosine methylation.
Bisulfite treatment followed by PCR amplification specifically converts unmethylated …

Abstract Analysis of DNA methylation patterns relies increasingly on sequencing-based profiling
methods. The four most frequently used sequencing-based technologies are the bisulfite…

Neoadjuvant ipilimumab + nivolumab (Ipi+Nivo) and nivolumab + chemotherapy (Nivo+CT)
induce greater pathologic response rates than CT alone in patients with operable non-small …

Sirtuin proteins regulate diverse cellular pathways that influence genomic stability, metabolism
and ageing 1 , 2 . SIRT7 is a mammalian sirtuin whose biochemical activity, molecular …

Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is treated as a
single entity with predictably poor results. Using tumor expression data and non-negative …

The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse
diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) …

Recent developments in next-generation sequencing have enabled whole-genome profiling
of nucleosome organizations. Although several algorithms for inferring nucleosome position …

The recognition of modified histones by "reader" proteins constitutes a key mechanism
regulating gene expression in the chromatin context. Compared with the great variety of readers …