[PDF][PDF] Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2
…, M Tian, L Fu, Y Gao, X Zhao, K Liu, J Qi, GF Gao… - Cell, 2022 - cell.com
The coronavirus disease 2019 (COVID-19) pandemic continues worldwide with many
variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron (B.1.1.529)…
variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron (B.1.1.529)…
[HTML][HTML] Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape
…, P Han, C Bai, P Han, A Zheng, L Fu, Y Gao… - Nature …, 2022 - nature.com
Omicron SARS-CoV-2 is rapidly spreading worldwide. To delineate the impact of emerging
mutations on spike’s properties, we performed systematic structural analyses on apo …
mutations on spike’s properties, we performed systematic structural analyses on apo …
[PDF][PDF] The architecture of inactivated SARS-CoV-2 with postfusion spikes revealed by cryo-EM and cryo-ET
C Liu, L Mendonça, Y Yang, Y Gao, C Shen, J Liu, T Ni… - Structure, 2020 - cell.com
The ongoing global pandemic of coronavirus disease 2019 (COVID-19) resulted from the
outbreak of SARS-CoV-2 in December 2019. Currently, multiple efforts are being made to …
outbreak of SARS-CoV-2 in December 2019. Currently, multiple efforts are being made to …
[HTML][HTML] An E2-E3 pair contributes to seed size control in grain crops
…, Z Zhao, X Liu, Y Sui, D Zhang, H Zhi, Y Gao… - Nature …, 2023 - nature.com
Understanding the molecular mechanisms that regulate grain yield is important for improving
agricultural productivity. Protein ubiquitination controls various aspects of plant growth but …
agricultural productivity. Protein ubiquitination controls various aspects of plant growth but …
[HTML][HTML] Pangenome analysis reveals genomic variations associated with domestication traits in broomcorn millet
Broomcorn millet (Panicum miliaceum L.) is an orphan crop with the potential to improve cereal
production and quality, and ensure food security. Here we present the genetic variations, …
production and quality, and ensure food security. Here we present the genetic variations, …
Viral architecture of SARS-CoV-2 with post-fusion spike revealed by Cryo-EM
C Liu, Y Yang, Y Gao, C Shen, B Ju, C Liu, X Tang… - BioRxiv, 2020 - biorxiv.org
Since December 2019, the outbreak of Coronavirus Disease 2019 (COVID-19) spread from
Wuhan, China to the world, it has caused more than 87,000 diagnosed cases and more than …
Wuhan, China to the world, it has caused more than 87,000 diagnosed cases and more than …
[HTML][HTML] Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
ClC-2 transports chloride ions across plasma membranes and plays critical roles in cellular
homeostasis. Its dysfunction is involved in diseases including leukodystrophy and primary …
homeostasis. Its dysfunction is involved in diseases including leukodystrophy and primary …
[HTML][HTML] Architecture of the baculovirus nucleocapsid revealed by cryo-EM
X Jia, Y Gao, Y Huang, L Sun, S Li, H Li… - Nature …, 2023 - nature.com
Baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) has been widely
used as a bioinsecticide and a protein expression vector. Despite their importance, very …
used as a bioinsecticide and a protein expression vector. Despite their importance, very …
[HTML][HTML] Directed natural evolution generates a next-generation oncolytic virus with a high potency and safety profile
…, D Song, R Shen, Z Liu, X Jia, Q Zhang, Y Gao… - Nature …, 2023 - nature.com
Oncolytic viruses (OVs) represent a type of encouraging multi-mechanistic drug for the
treatment of cancer. However, attenuation of virulence, which is generally required for the …
treatment of cancer. However, attenuation of virulence, which is generally required for the …
[HTML][HTML] Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA. 1-BA. 5
Y Wang, A Yan, D Song, C Dong, M Rao, Y Gao, R Qi… - Cell Discovery, 2023 - nature.com
SARS-CoV-2 Omicron subvariants have demonstrated extensive evasion from monoclonal
antibodies (mAbs) developed for clinical use, which raises an urgent need to develop new …
antibodies (mAbs) developed for clinical use, which raises an urgent need to develop new …