Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, …

Insulin-like growth factor 1 (IGF-1) has been implicated in promoting mitogenic, metastatic
and antiapoptotic phenotypes in several types of cancer. But little is known about the signal …

The role of the mTOR inhibitor, rapamycin, in regulation of adiposity remains controversial.
Here, we evaluate mTOR signaling in lipid metabolism in adipose tissues of Lmna −/− mice, a …

The potassium chloride cotransporter (KCC) is a major determinant of osmotic homeostasis
and plays an emerging role in tumor biology. Here, we investigate if KCC is involved in the …

The mechanisms by which insulin-like growth factor 1 (IGF-1) cooperates with membrane
ion transport system to modulate epithelial cell motility and proliferation remain poorly …

Cervical cancer is a major world health problem for women, but the pathophysiology of this
disease has received scant attention. Here we show that the growth and invasion of cervical …

Autophagy, a process catabolizing intracellular components to maintain energy homeostasis,
impacts aging and metabolism. Spermidine, a natural polyamine and autophagy activator, …

The cellular function of electroneutral K‐Cl cotransport (KCC) is to regulate epithelial ion
transport and osmotic homeostasis. Here we investigate the mechanisms by which insulin‐like …

Evergreen broad‐leaved forest was studied in a transect on the northwestern slope of Mount
Lopei in order to reveal altitudinal zonation in structure and floristic composition and the …

Physiological and premature aging are frequently associated with an accumulation of prelamin
A, a precursor of lamin A, in the nuclear envelope of various cell types. Here, we aimed to …