Cancer is a disease of aging fueled by the accumulation of somatic mutations. While mutations
in tumors are well characterized, little is known about the early mutational processes that …

We addressed the precursor role of aging-like spontaneous promoter DNA hypermethylation
in initiating tumorigenesis. Using mouse colon-derived organoids, we show that promoter …

Next-generation sequencing methods suffer from low recovery, uneven coverage, and false
mutations. DNA fragmentation by sonication is a major contributor to these problems …

10.7554/eLife.28070.001 Cells of multi-cellular organisms evolve toward uni-cellularity in
the form of cancer and, if humans intervene, continue to evolve in cell culture. During this …

AIM: To develop a prognostic gene set that can predict patient overall survival status based
on the whole genome expression analysis. METHODS: Using Illumina HumanWG-6 …

Large genomes with elevated mutation rates are prone to accumulating deleterious mutations
more rapidly than natural selection can purge (Muller’s ratchet). As a consequence, it may …

Chromosomal inversion is an important type of genomic variations involved in both
evolution and disease pathogenesis. Here, we describe the refined genetic structure of a 3.8‐Mb …

The distribution of discontinuities in the deep stratigraphic rock mass is random and irregular,
and the spatial distribution has statistical self-similarity, which can be analyzed by fractal …

Ferroelectrics can significantly boost electrochemical performances of all‐solid‐state
batteries by constructing built‐in electric field to reduce the space charge layer at cathode/solid‐…

Classical r- vs. K-selection theory describes the trade-offs between high reproductive output
and competitiveness and guides research in evolutionary ecology. While its impact has …