Higher-order chromosomal organization for transcription regulation is poorly understood in
eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag …

Exfoliation syndrome (XFS) is the most common recognizable cause of open-angle
glaucoma worldwide. To better understand the etiology of XFS, we conducted a genome-wide …

Long-range chromatin contacts between specific DNA regulatory elements play a pivotal role
in gene expression regulation, and a global characterization of these interactions in the 3-…

The recent advent of third-generation sequencing technologies brings promise for better
characterization of genomic structural variants by virtue of having longer reads. However, long-…

Most mammalian genes generate messenger RNAs with variable untranslated regions (UTRs)
that are important post-transcriptional regulators. In cancer, shortening at 3′ UTR ends …

Stretched histone regions, such as super-enhancers and broad H3K4me3 domains, are
associated with maintenance of cell identity and cancer. We connected super-enhancers and …

IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis. Previously
identified genome-wide association study (GWAS) loci explain only a fraction of disease risk. …

Adenosine-to-inosine RNA editing, which is catalyzed by adenosine deaminases acting on
RNA (ADAR) family of enzymes, ADAR1 and ADAR2, has been shown to contribute to …

Genomes are organized into three-dimensional structures, adopting higher-order conformations
inside the micron-sized nuclear spaces 7, 2, 12. Such architectures are not random and …

It has been shown that the filamentous phage, Pf4, plays an important role in biofilm development,
stress tolerance, genetic variant formation and virulence in Pseudomonas aeruginosa …