Interleukin-27 is a pleiotropic cytokine whose functions during bacterial infections remain
controversial, and its role in patients with S. aureus osteomyelitis is unknown. To address this …

Osteomyelitis is a devastating disease caused by microbial infection of bone. While the
frequency of infection following elective orthopedic surgery is low, rates of reinfection are …

Background Polygenic risk score (PRS) analysis is used to predict disease risk. Although
PRS has been shown to have great potential in improving clinical care, PRS accuracy …

Innate and adaptive immune responses against pathogens are known to be carefully
orchestrated by specific cytokines that initiate and down regulate immune cell functions from the …

The aims of this study were to investigate the influence of subchondral bone fragility (SBF)
on the progression of the knee osteoarthritis by using a novel rat model, and to examine the …

Introduction The relationship between postoperative tibiofemoral ligament balance and patient
satisfaction in total knee arthroplasty (TKA) has been explored previously. However, the …

Staphylococcus aureus is prevalent in surgical site infections (SSI) and leads to death in
approximately 1% of patients. Phase IIB/III clinical trial results have demonstrated that …

Osteomyelitis is a devastating complication of orthopaedic surgery and commonly caused
by Staphylococcus aureus (S. aureus) and Group B Streptococcus (GBS, S. agalactiae). …

Poor clinical outcomes are reported in excessive flexion of the femoral component in total
knee arthroplasty (TKA), but their mechanisms have not yet been elucidated. This study aimed …

Several concepts may be used to restore normal knee kinematics after total knee arthroplasty.
One is a kinematically aligned (KA) technique, which restores the native joint line and limb …