Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney
tissue atlas in health and disease with single-cell resolution. Here, we describe the …

Creating a cDNA library for deep mRNA sequencing (mRNAseq) is generally done by
random priming, creating multiple sequencing fragments along each transcript. A 3′-end-focused …

Cell motility is important for many developmental and physiological processes. Motility
arises from interactions between physical forces at the cell surface membrane and the …

Kinase inhibitors (KIs) represent an important class of anti-cancer drugs. Although
cardiotoxicity is a serious adverse event associated with several KIs, the reasons remain poorly …

Kidney fibrosis constitutes the shared final pathway of nearly all chronic nephropathies, but
biomarkers for the non-invasive assessment of kidney fibrosis are currently not available. To …

Introduction: Tyrosine kinase inhibitor drugs (TKIs) are highly effective cancer drugs, yet many
TKIs are associated with various forms of cardiotoxicity. The mechanisms underlying these …

Acute kidney injury (AKI) induces a broad range of clinically significant perturbations in
kidney morphology and function. Insights into the molecular and cellular basis governing a …

We present the BioDepot-workflow-builder (Bwb), a software tool that allows users to create
and execute reproducible bioinformatics workflows using a drag-and-drop interface. …

Cell spreading is regulated by signaling from the integrin receptors that activate intracellular
signaling pathways to control actin filament regulatory proteins. We developed a hybrid …

Chronic kidney disease (CKD) and acute kidney injury (AKI) are heterogeneous syndromes
defined clinically by serial measures of kidney function. Each condition possesses strong …