Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of the …

Proteins in the karyopherin-β family mediate the majority of macromolecular transport between
the nucleus and the cytoplasm. Eleven of the 19 known human karyopherin-βs and 10 of …

The Karyopherin-β family of nuclear transport factors mediates the majority of nucleocytoplasmic
transport. Although each of the 19 Karyopherin-βs transports unique sets of cargos, …

Karyopherinβ (Kapβ) proteins bind nuclear localization and export signals (NLSs and NESs)
to mediate nucleocytoplasmic trafficking, a process regulated by Ran GTPase through its …

Transport factors in the karyopherin-β (also called importin-β) family mediate the movement
of macromolecules in nuclear–cytoplasmic transport pathways. Karyopherin-β2 (transportin) …

RNA-binding proteins (RBPs) with prion-like domains (PrLDs) phase transition to functional
liquids, which can mature into aberrant hydrogels composed of pathological fibrils that …

The nuclear export protein XPO1 is overexpressed in cancer, leading to the cytoplasmic
mislocalization of multiple tumor suppressor proteins. Existing XPO1-targeting agents lack …

CRM1 (also known as XPO1 and exportin 1) mediates nuclear export of hundreds of
proteins through the recognition of the leucine-rich nuclear export signal (LR-NES). Here we …

Liquid-liquid phase separation (LLPS) is believed to underlie formation of biomolecular
condensates, cellular compartments that concentrate macromolecules without surrounding …

We have solved the structure of a chorismate mutase (chorismate pyruvatemutase, EC 5.4.99.5),
the 1.9-A crystal structure of the monofunctional enzyme from Bacillus subtilis. The …