Dysfunction of autophagy, which regulates cellular homeostasis by degrading organelles
and proteins, is associated with pathogenesis of various diseases such as cancer, …

Whether obesity accelerates or suppresses autophagy in adipose tissue is still debatable.
To clarify dysregulation of autophagy and its role in pathologies of obese adipose tissue, we …

HBx Protein Contributes to Liver Carcinogenesis by H3K4me3 M... : Hepatology HBx Protein
Contributes to Liver Carcinogenesis by H3K4me3 Modification Through Stabilizing WD …

Peroxisome proliferator-activated receptor α (PPARα) is a therapeutic target for
hyperlipidemia. Pemafibrate (K-877) is a new selective PPARα modulator activating PPARα …

Brown adipose tissue (BAT) is an attractive therapeutic target for treating obesity and
metabolic diseases. Octacosanol is the main component of policosanol, a mixture of very long …

Obesity causes various health problems, such as type 2 diabetes, non-alcoholic fatty liver
disease, and cardio- and cerebrovascular diseases. Metabolic organs, particularly white …

Obesity, caused by the dysfunction of white adipose tissue (WAT), is reportedly accompanied
by exacerbation of lipolysis. Perilipin 1 (PLIN1), which forms a coat around lipid droplets, …

Caloric restriction (CR) improves whole body metabolism, suppresses age-related
pathophysiology, and extends lifespan in rodents. Metabolic remodeling, including fatty acid (FA) …

Alterations in adipocyte characteristics are highly implicated in the pathology of obesity. In a
recent article, we demonstrated that high-fat diet-induced obesity impairs lysosomal function…

Engineered synthetic biomolecular devices that integrate elaborate information processing
and precisely regulate living cell behavior have potential in various applications. Although …