The basic helix-loop-helix transcription factors Ascl1/Mash1, Hes1, and Olig2 regulate fate
choice of neurons, astrocytes, and oligodendrocytes, respectively. These same factors are …

A bilateral pair of somites forms periodically by segmentation of the anterior ends of the
presomitic mesoderm (PSM). This periodic event is regulated by a biological clock called the …

Somatic stem/progenitor cells are active in embryonic tissues but quiescent in many adult
tissues. The detailed mechanisms that regulate active versus quiescent stem cell states are …

Periodic somite segmentation is controlled by the cyclic gene Hes7, whose oscillatory
expression depends upon negative feedback with a delayed timing. The mechanism that …

Formation of the body of vertebrate embryos proceeds sequentially by posterior addition of
tissues from the tail bud. Cells of the tail bud and the posterior presomitic mesoderm, which …

Somites, metameric structures, give rise to the vertebral column, ribs, skeletal muscles and
subcutaneous tissues. In mouse embryos, a pair of somites is formed every 2 h by …

Somitogenesis is controlled by the segmentation clock, where the oscillatory expression of
cyclic genes such as Hes7 leads to the periodic expression of Mesp2, a master gene for …

The Notch signaling effectors Hes1 and Hes7 exhibit oscillatory expression with a period of
about 2–3 h during embryogenesis. Hes1 oscillation is important for proliferation and …

Treatment of 6-(1-methylhydrazino) uracil (I) with phenacyl bromides in methoxyethanol
afforded the corresponding 3-aryl-1-methylpyrimido [4, 5-c] pyridazine-5, 7 (1H, 6H)-diones (3-…

The kinetics of the degradation of cefotiam in aqueous solution was studied at 25 C and an
ionic strength of 0.6 over the pH range of 2 to 12. The degradation was a pseudo first order …