TIE-1 and Tie-2 define a new class of receptor tyrosine kinases that are specifically expressed
in developing vascular endothelial cells. To study the functions of Tie-1 and Tie-2 during …

Trimethylation on H3K27 (H3K27me3) mediated by Polycomb repressive complex 2 (PRC2)
has been linked to embryonic stem cell (ESC) identity and pluripotency. EZH2, the catalytic …

The X chromosome-linked transcription factor GATA-1 is expressed specifically in erythroid,
mast, megakaryocyte, and eosinophil lineages, as well as in hematopoietic progenitors. …

Reactive oxygen species are involved in many cellular metabolic and signalling processes
1 and are thought to have a role in disease, particularly in carcinogenesis and ageing 2 . We …

The hematopoietic transcription factor GATA-1 is essential for development of the erythroid
and megakaryocytic lineages. Using the conserved zinc finger DNA-binding domain of GATA-…

Enhancers, critical determinants of cellular identity, are commonly recognized by correlative
chromatin marks and gain-of-function potential, although only loss-of-function studies can …

The T cell leukemia oncoprotein SCL/tal-1, a basic–helix-loop-helix transcription factor, is
required for production of embryonic red blood cells in the mouse yolk sac. To define roles in …

Transcription factor GATA‐1 is essential for red blood cell maturation and, therefore, for survival
of developing mouse embryos. GATA‐1 is also expressed in megakaryocytes, mast cells…

The reduction of iron is an essential step in the transferrin (Tf) cycle, which is the dominant
pathway for iron uptake by red blood cell precursors. A deficiency in iron acquisition by red …

XRCC4 was identified via a complementation cloning method that employed an ionizing
radiation (IR)-sensitive hamster cell line. By gene-targeted mutation, we show that XRCC4 …