The optimal source of stem cells for regenerative medicine is a major question. Embryonic
stem (ES) cells have shown promise for pluripotency but have ethical issues and potential to …

Using antibodies that recognize either tyrosinase, tyrosinase-related protein-1 (TRP1), or
tyrosinase-related protein-2 (TRP2, DOPAchrome tautomerase), the quantities of those …

Interleukin-18 (IL-18) is a novel cytokine that plays an important role in the T-helper 1 (Th1)
response, primarily via its ability to induce IFN-γ production in T cells and NK cells. Human …

Nestin‐positive, keratin 15 (K15)‐negative multipotent hair follicle stem cells are located
above the hair follicle bulge. We have termed this location the hair follicle pluripotent stem cell …

VCP/p97 is involved in a variety of cellular processes, including membrane fusion and
ubiquitin-dependent protein degradation. It has been suggested that adaptor proteins such as …

We have previously demonstrated that the neural stem-cell marker nestin is expressed in
hair follicle stem cells located in the bulge area which are termed hair-follicle-associated …

Seasonal allergic rhinitis (SAR) to the Japanese cedar, Cryptomeria japonica (JC) pollen is
an IgE-mediated type I allergy affecting nasal mucosa. However, the molecular events …

The generation of induced pluripotent stem cells (iPSCs) by introducing reprogramming
factors into somatic cells is a promising method for stem cell therapy in regenerative medicine. …

Genetically modified mouse models are essential for in vivo investigation of gene function
and human disease research. Targeted mutations can be introduced into mouse embryos …

Genome editing can introduce designed mutations into a target genomic site. Recent
research has revealed that it can also induce various unintended events such as structural …