AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism.
When activated by a deficit in nutrient status, AMPK stimulates glucose uptake and lipid …

AMP-activated protein kinase (AMPK) is a heterotrimeric protein that regulates glucose
transport mediated by cellular stress or pharmacological agonists such as 5-aminoimidazole-4-…

Interleukin (IL)-6 is a proinflammatory cytokine shown to modify insulin sensitivity. Elevated
plasma levels of IL-6 are observed in insulin-resistant states. Interestingly, plasma IL-6 levels …

Type 2 (non-insulin-dependent) diabetes mellitus is a progressive metabolic disorder arising
from genetic and environmental factors that impair beta cell function and insulin action in …

Autophagy is an evolutionarily conserved and exquisitely regulated self-eating cellular
process with important biological functions. Phosphatidylinositol 3-kinases (PtdIns3Ks) and …

Coordination of skeletal muscle growth and metabolism with nutrient availability is critical
for metabolic homeostasis. To establish the role of insulin-like signaling in this process, we …

Activation of autophagy and elevation of glutamine synthesis represent key adaptations to
maintain amino acid balance during starvation. In this study, we investigate the role of …

Although essential amino acids regulate mechanistic target of rapamycin complex 1 (mTORC1)
and the integrated stress response (ISR), the role of cysteine is unknown. We found that …

Exercise training improves glucose homeostasis through enhanced insulin sensitivity in
skeletal muscle. Muscle contraction through physical exercise is a physiological stimulus that …

The metabolic property of skeletal muscle adapts in response to an increased physiological
demand by altering substrate utilization and gene expression. The calcium-regulated serine/…