Background Diabetes mellitus is an important risk factor for atrial fibrillation (AF) development.
Sodium–glucose co-transporter-2 (SGLT-2) inhibitors are used for the treatment of type 2 …

In the heart, autophagy has been implicated in cardioprotection and ischemia-reperfusion
tolerance, and the dysregulation of autophagy is associated with the development of heart …

The primary recognized function of cytochromec is to act as an electron carrier transferring
electrons from complex III to complex IV in the respiratory chain of mitochondria. Recent …

MicroRNAs (miRNAs) are short non-coding RNA regulators that control gene expression
mainly through post-transcriptional silencing. We previously identified miR-205 in a signature …

Mitochondrial cristae are the main site for oxidative phosphorylation, which is critical for
cellular energy production. Upon different physiological or pathological stresses, mitochondrial …

Background: Oxidative stress contributes to adverse atrial remodeling in diabetes mellitus.
This remodeling can be prevented by the PPAR-γ agonist pioglitazone via its antioxidant and …

Mitochondrial oxidative stress and dysfunction play an important role of atrial remodeling
and atrial fibrillation (AF) in diabetes mellitus. Endoplasmic reticulum (ER) stress has been …

Rationale Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are important
mechanisms of atrial remodeling, predisposing to the development of atrial fibrillation (AF) in …

Background There is increasing evidence implicating atrial mitochondrial dysfunction in the
pathogenesis of atrial fibrillation. In this study, we explored whether alogliptin, a dipeptidyl …

Temporal absences in observation records lead to release losses during the source term
inversions of atmospheric radionuclide emissions. Consequently, objectively-estimated source …