Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection
COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play a key
role in the adaptive antiviral immune response by killing infected cells and facilitating the …
role in the adaptive antiviral immune response by killing infected cells and facilitating the …
Distinctive properties of identical twins' TCR repertoires revealed by high-throughput sequencing
…, DM Chudakov, YB Lebedev… - Proceedings of the …, 2014 - National Acad Sciences
Adaptive immunity in humans is provided by hypervariable Ig-like molecules on the surface
of B and T cells. The final set of these molecules in each organism is formed under the …
of B and T cells. The final set of these molecules in each organism is formed under the …
[HTML][HTML] Detecting T cell receptors involved in immune responses from single repertoire snapshots
…, M Shugay, DM Chudakov, YB Lebedev… - PLoS …, 2019 - journals.plos.org
Hypervariable T cell receptors (TCRs) play a key role in adaptive immunity, recognizing a vast
diversity of pathogen-derived antigens. Our ability to extract clinically relevant information …
diversity of pathogen-derived antigens. Our ability to extract clinically relevant information …
Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins
…, T Mora, AM Walczak, YB Lebedev - Proceedings of the …, 2018 - National Acad Sciences
T cell receptor (TCR) repertoire data contain information about infections that could be used
in disease diagnostics and vaccine development, but extracting that information remains a …
in disease diagnostics and vaccine development, but extracting that information remains a …
[HTML][HTML] Solitary HERV-K LTRs possess bi-directional promoter activity and contain a negative regulatory element in the U5 region
…, EP Kopantzev, EV Snezhkov, YB Lebedev… - FEBS letters, 2000 - Elsevier
Reporter gene analysis of HERV-K solitary long terminal repeats (LTRs) showed that they
retain detectable activity in human teratocarcinoma cells, and can direct the transcription in …
retain detectable activity in human teratocarcinoma cells, and can direct the transcription in …
Quantitative tracking of T cell clones after haematopoietic stem cell transplantation
…, S Lukyanov, DM Chudakov, YB Lebedev - EMBO molecular …, 2011 - embopress.org
Autologous haematopoietic stem cell transplantation is highly efficient for the treatment of
systemic autoimmune diseases, but its consequences for the immune system remain poorly …
systemic autoimmune diseases, but its consequences for the immune system remain poorly …
[HTML][HTML] Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones
…, A Franke, D Chudakov, IZ Mamedov, YB Lebedev… - Elife, 2020 - elifesciences.org
The diverse repertoire of T-cell receptors (TCR) plays a key role in the adaptive immune
response to infections. Using TCR alpha and beta repertoire sequencing for T-cell subsets, as …
response to infections. Using TCR alpha and beta repertoire sequencing for T-cell subsets, as …
Method for identification of condition-associated public antigen receptor sequences
…, DM Chudakov, IZ Mamedov, YB Lebedev… - Elife, 2018 - elifesciences.org
10.7554/eLife.33050.001 Diverse repertoires of hypervariable immunoglobulin receptors (TCR
and BCR) recognize antigens in the adaptive immune system. The development of …
and BCR) recognize antigens in the adaptive immune system. The development of …
[HTML][HTML] The evidence for increased L1 activity in the site of human adult brain neurogenesis
…, KV Khodosevich, IZ Mamedov, YB Lebedev - PLoS …, 2015 - journals.plos.org
Retroelement activity is a common source of polymorphisms in human genome. The
mechanism whereby retroelements contribute to the intraindividual genetic heterogeneity by …
mechanism whereby retroelements contribute to the intraindividual genetic heterogeneity by …
Differences in HERV-K LTR insertions in orthologous loci of humans and great apes
YB Lebedev, OS Belonovitch, NV Zybrova, PP Khil… - Gene, 2000 - Elsevier
The classification of the long terminal repeats (LTRs) of the human endogenous retrovirus
HERV-K (HML-2) family was refined according to diagnostic differences between the LTR …
HERV-K (HML-2) family was refined according to diagnostic differences between the LTR …