Discoveries in human genetic studies have revolutionized our understanding of complex
rheumatic and autoimmune diseases, including the identification of hundreds of genetic loci …

The emerging diversity of single-cell RNA-seq datasets allows for the full transcriptional
characterization of cell types across a wide variety of biological and clinical conditions. However, …

Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis, 5–15% will
develop active tuberculosis (TB). Approximately half will progress to active TB within the first 18 …

Non-coding genetic variants may cause disease by modulating gene expression. However,
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …

Background Diagnosis of systemic autoimmune rheumatic diseases (SARD) relies on the
presence of hallmark anti-nuclear antibodies (ANA), many of which can be detected years …

The transcription factor AhR modulates immunity at multiple levels. Here we report that
phagocytes exposed to apoptotic cells exhibited rapid activation of AhR, which drove production …

Objective Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown origin
in which interleukin (IL) 17 has been genetically and therapeutically recognised as a key …

Objective To identify an immunologic basis for the male sex bias in ankylosing spondylitis (AS).
Methods Cohorts of male and female patients with AS and age‐ and sex‐matched …

Multimodal T cell profiling can enable more precise characterization of elusive cell states
underlying disease. Here, we integrated single-cell RNA and surface protein data from 500,089 …

Genetic studies have revealed that autoimmune susceptibility variants are over-represented
in memory CD4 + T cell regulatory elements 1 , 2 – 3 . Understanding how genetic variation …