Detecting selective sweeps from genomic SNP data is complicated by the intricate ascertainment
schemes used to discover SNPs, and by the confounding influence of the underlying …

The theory of genetic hitchhiking predicts that the level of genetic variation is greatly reduced
at the site of strong directional selection and increases as the recombinational distance …

The hitchhiking effect of a beneficial mutation, or a selective sweep, generates a unique
distribution of allele frequencies and spatial distribution of polymorphic sites. A composite-…

The process of strong artificial selection during a domestication event is modeled, and its
effect on the pattern of DNA polymorphism is investigated. The model also considers …

In 2002 Kim and Stephan proposed a promising composite-likelihood method for localizing
and estimating the fitness advantage of a recently fixed beneficial mutation. Here, we …

The human caspase-12 gene is polymorphic for the presence or absence of a stop codon,
which results in the occurrence of both active (ancestral) and inactive (derived) forms of the …

Due to relatively high rates of strongly selected deleterious mutations, directional selection on
favorable alleles (causing hitchhiking effects on linked neutral polymorphisms) is expected …

Many perspectives on the role of evolution in human health include nonempirical assumptions
concerning the adaptive evolutionary origins of human diseases. Evolutionary analyses …

The evolution of resistance in Plasmodium falciparum against safe and affordable drugs such
as chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) is a major global health threat. …

Fisher and Muller's theory that recombination speeds adaptation by eliminating competition
among beneficial mutations has proved a popular explanation for the advantage of sex. …