Growing evidence indicates that microRNAs (miRNAs or miRs) are involved in basic cell
functions and oncogenesis. Here we report that miR-133 has a critical role in determining …

Amplification of the gene encoding the ErbB2 (Her2/neu) receptor tyrosine kinase is critical
for the progression of several forms of breast cancer. In a large-scale clinical trial, treatment …

Biomechanical stress is a major stimulus for cardiac hypertrophy and the transition to heart
failure. By generating mice that harbor a ventricular restricted knockout of the gp130 cytokine …

Activation and accumulation of cardiac fibroblasts, which result in excessive extracellular matrix
deposition and consequent mechanical stiffness, myocyte uncoupling, and ischemia, are …

Dilated cardiomyopathy and end-stage heart failure result in multiple defects in cardiac
excitation–contraction coupling. Via complementation of a genetically based mouse model of …

The serine-threonine kinase Akt seems to be central in mediating stimuli from different
classes of receptors. In fact, both IGF-1 and IL6-like cytokines induce hypertrophic and …

Caveolins are important components of caveolae, which have been implicated in vesicular
trafficking and signal transduction. To investigate the in vivo significance of Caveolins in …

Pericytes are widely believed to function as mesenchymal stem cells (MSCs), multipotent
tissue-resident progenitors with great potential for regenerative medicine. Cultured pericytes …

KChIP2, a gene encoding three auxiliary subunits of Kv4.2 and Kv4.3, is preferentially
expressed in the adult heart, and its expression is downregulated in cardiac hypertrophy. Mice …

Ca 2+ /calmodulin–dependent kinase II (CaMKII) has been implicated in cardiac hypertrophy
and heart failure. We generated mice in which the predominant cardiac isoform, CaMKIIδ, …