Blockchain, which is a technology for distributedly managing ledger information over
multiple nodes without a centralized system, has elicited increasing attention. Performing …

Background/Aim: Rectal cancer is a recalcitrant disease with limited treatment options. Pre-clinical
studies have shown the efficacy of methionine restriction with a low-methionine diet …

Methionine addiction, a fundamental and general hallmark of cancer, known as the Hoffman
Effect, is due to altered use of methionine for increased and aberrant transmethylation …

Background/Aim: Methionine addiction is a fundamental and general hallmark of cancer,
termed the Hoffman effect. Methionine addiction is due to excessive use of and dependence on …

All cancer cell types are methionine-addicted, which is termed the Hoffman effect. Cancer
cells, unlike normal cells, cannot survive without large amount of methionine. In general, when …

Positron emission tomography (PET) is widely used to detect cancers. The usual isotope for
PET imaging of cancer is [ 18 F]deoxyglucose. The premise of using [ 18 F]deoxyglucose is …

Background: Pancreatic cancer is one of the most recalcitrant cancers, and more effective
therapy is needed. Pre-clinical studies have shown that patient-derived orthotopic xenograft (…

Blockchains have attracted a great deal of attention as a technology for the distributed
management of register information at multiple nodes without a centralized system. However, they …

Background/Aim: Invasive lobular carcinoma (ILC) of the breast has a low complete-response
rate in the neoadjuvant-chemotherapy setting. The addiction to methionine is a …

Bitcoin has a low transaction throughput. In order to allow for an increase of this throughput
without increasing orphan blocks, decreasing the block propagation time is important. One of …