[HTML][HTML] Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7
…, J Sakai, M Makita, J Noda, M Mori, Y Higashi… - … et Biophysica Acta (BBA …, 2004 - Elsevier
Recent studies have revealed the presence of intracellular lipid droplets in wide variety of
species. In mammalian cells, there exist proteins specifically localize in lipid droplets. However…
species. In mammalian cells, there exist proteins specifically localize in lipid droplets. However…
IGF-1 reduces inflammatory responses, suppresses oxidative stress, and decreases atherosclerosis progression in ApoE-deficient mice
S Sukhanov, Y Higashi, SY Shai… - … , and vascular biology, 2007 - Am Heart Assoc
Objective— Whereas growth factors, via their ability to stimulate vascular smooth muscle
cell (VSMC) proliferation and migration, have been thought to play a permissive role in …
cell (VSMC) proliferation and migration, have been thought to play a permissive role in …
Aging, atherosclerosis, and IGF-1
Y Higashi, S Sukhanov, A Anwar… - … Series A: Biomedical …, 2012 - academic.oup.com
Insulin-like growth factor 1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that
circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major …
circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major …
[HTML][HTML] Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7
…, M Mori, S Yamaguchi, M Makita, Y Higashi… - Journal of lipid …, 2007 - ASBMB
Lipid droplets (LDs) function as intracellular storage depots of neutral lipids. Recently, we
identified long-chain acyl-coenzyme A synthetase 3 (ACSL3) as a major LD-associated protein …
identified long-chain acyl-coenzyme A synthetase 3 (ACSL3) as a major LD-associated protein …
Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia
Cachexia is a serious complication of many chronic diseases, such as congestive heart failure
(CHF) and chronic kidney disease (CKD). Many factors are involved in the development …
(CHF) and chronic kidney disease (CKD). Many factors are involved in the development …
Angiotensin II, oxidative stress and skeletal muscle wasting
Muscle atrophy (cachexia) is a muscle wasting syndrome associated with several pathological
conditions in humans such as congestive heart failure, diabetes, AIDS, cancer and renal …
conditions in humans such as congestive heart failure, diabetes, AIDS, cancer and renal …
IGF-1, oxidative stress and atheroprotection
Y Higashi, S Sukhanov, A Anwar, SY Shai… - Trends in Endocrinology …, 2010 - cell.com
Atherosclerosis is a chronic inflammatory disease in which early endothelial dysfunction and
subintimal modified lipoprotein deposition progress to complex, advanced lesions that are …
subintimal modified lipoprotein deposition progress to complex, advanced lesions that are …
IGF-1 and cardiovascular disease
Y Higashi, S Gautam, P Delafontaine… - Growth Hormone & IGF …, 2019 - Elsevier
Atherosclerosis is an inflammatory arterial pathogenic condition, which leads to ischemic
cardiovascular diseases, such as coronary artery disease and myocardial infarction, stroke, …
cardiovascular diseases, such as coronary artery disease and myocardial infarction, stroke, …
Long-chain fatty acids induce lipid droplet formation in a cultured human hepatocyte in a manner dependent of Acyl-CoA synthetase
…, S Yamaguchi, M Mori, Y Higashi… - Biological and …, 2006 - jstage.jst.go.jp
MATERIALS AND METHODS Materials HuH7, a human hepatocyte cell line, was obtained
from Health Science Research Resources Bank (cell no. JCRB0403; Osaka Japan). Fatty …
from Health Science Research Resources Bank (cell no. JCRB0403; Osaka Japan). Fatty …
Insulin-like growth factor-1 receptor deficiency in macrophages accelerates atherosclerosis and induces an unstable plaque phenotype in apolipoprotein E–deficient …
Y Higashi, S Sukhanov, SY Shai, S Danchuk, R Tang… - Circulation, 2016 - Am Heart Assoc
Background— We have previously shown that systemic infusion of insulin-like growth factor-1
(IGF-1) exerts anti-inflammatory and antioxidant effects and reduces atherosclerotic …
(IGF-1) exerts anti-inflammatory and antioxidant effects and reduces atherosclerotic …