A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement

…, K Fragaki, L Berg-Alonso, Y Kageyama… - Brain, 2014 - academic.oup.com
Mitochondrial DNA instability disorders are responsible for a large clinical spectrum, among
which amyotrophic lateral sclerosis-like symptoms and frontotemporal dementia are …

Parkin‐independent mitophagy requires D rp1 and maintains the integrity of mammalian heart and brain

Y Kageyama, M Hoshijima, K Seo, D Bedja… - The EMBO …, 2014 - embopress.org
Mitochondrial dynamics and mitophagy have been linked to cardiovascular and neurodegenerative
diseases. Here, we demonstrate that the mitochondrial division dynamin D rp1 and …

[PDF][PDF] Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors

…, JJ Asciolla, JL Yao, O Jabado, K Hoehn, Y Kageyama… - Molecular cell, 2015 - cell.com
Mitochondrial division is essential for mitosis and metazoan development, but a mechanistic
role in cancer biology remains unknown. Here, we examine the direct effects of oncogenic …

Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage

Y Kageyama, Z Zhang, R Roda, M Fukaya… - Journal of Cell …, 2012 - rupress.org
Mitochondria divide and fuse continuously, and the balance between these two processes
regulates mitochondrial shape. Alterations in mitochondrial dynamics are associated with …

Treatment of hypertensive cerebellar hemorrhage–surgical or conservative management?

S Kobayashi, A Sato, Y Kageyama, H Nakamura… - …, 1994 - journals.lww.com
ONE HUNDRED AND one consecutive patients with hypertensive cerebellar hemorrhage
were analyzed to determine the criteria for surgery. New criteria based on the patient's …

CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis

…, F Burté, S Lacas‐Gervais, Y Kageyama… - EMBO molecular …, 2016 - embopress.org
CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired
mitochondrial genome maintenance and inhibition of apoptosis | EMBO Molecular Medicine All …

Mitochondrial division: molecular machinery and physiological functions

Y Kageyama, Z Zhang, H Sesaki - Current opinion in cell biology, 2011 - Elsevier
Mitochondrial division has emerged as a key mechanism for this essential organelle to
maintain its structural integrity, intracellular distribution, and functional competence. An …

Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease

WR Bell, Y An, Y Kageyama, C English, GL Rudow… - Alzheimer's & …, 2019 - Elsevier
Introduction Primary age-related tauopathy (PART) is a recently described entity that can
cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared …

Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43

…, W Bell, KD LaClair, JP Ling, H Han, Y Kageyama… - Acta …, 2017 - Springer
Abnormal accumulation of TDP-43 into cytoplasmic or nuclear inclusions with accompanying
nuclear clearance, a common pathology initially identified in amyotrophic lateral sclerosis (…

[HTML][HTML] Diffeomorphic registration with intensity transformation and missing data: Application to 3D digital pathology of Alzheimer's disease

D Tward, T Brown, Y Kageyama, J Patel… - Frontiers in …, 2020 - frontiersin.org
This paper examines the problem of diffeomorphic image registration in the presence of
differing image intensity profiles and sparsely sampled, missing, or damaged tissue. Our …