User profiles for Yusuke Sekine
 | Yusuke SekineUniversity of Pittsburgh Verified email at pitt.edu Cited by 1561 |
Mutations in a translation initiation factor identify the target of a memory-enhancing compound
Y Sekine, A Zyryanova, A Crespillo-Casado… - Science, 2015 - science.org
The integrated stress response (ISR) modulates messenger RNA translation to regulate the
mammalian unfolded protein response (UPR), immunity, and memory formation. A chemical …
mammalian unfolded protein response (UPR), immunity, and memory formation. A chemical …
Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B
The integrated stress response (ISR) is a conserved translational and transcriptional
program affecting metabolism, memory, and immunity. The ISR is mediated by stress-induced …
program affecting metabolism, memory, and immunity. The ISR is mediated by stress-induced …
Evaluation of off-state current characteristics of transistor using oxide semiconductor material, indium–gallium–zinc oxide
K Kato, Y Shionoiri, Y Sekine, K Furutani… - Japanese Journal of …, 2012 - iopscience.iop.org
We measured a significantly low off-state current (135 yA/µm at 85 C) of a metal oxide
semiconductor (MOS) transistor using indium–gallium–zinc oxide (IGZO), which is an oxide …
semiconductor (MOS) transistor using indium–gallium–zinc oxide (IGZO), which is an oxide …
A mitochondrial iron-responsive pathway regulated by DELE1
Y Sekine, R Houston, EM Eckl, E Fessler, DP Narendra… - Molecular Cell, 2023 - cell.com
The heme-regulated kinase HRI is activated under heme/iron deficient conditions; however,
the underlying molecular mechanism is incompletely understood. Here, we show that iron-…
the underlying molecular mechanism is incompletely understood. Here, we show that iron-…
Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1
Phosphoglycerate mutase (PGAM) is an enzyme of intermediary metabolism that converts 3-phosphoglycerate
to 2-phosphoglycerate in glycolysis. Here, we discovered PGAM5 that is …
to 2-phosphoglycerate in glycolysis. Here, we discovered PGAM5 that is …
The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases
Y Sekine, K Takeda, H Ichijo - Current molecular medicine, 2006 - ingentaconnect.com
Accumulation of unfolded and/or misfolded proteins in the endoplasmic reticulum (ER) lumen
induces ER stress. ER stress triggers the unfolded protein response (UPR), which includes …
induces ER stress. ER stress triggers the unfolded protein response (UPR), which includes …
The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses
K Mosallanejad, Y Sekine, S Ishikura-Kinoshita… - Science …, 2014 - science.org
During infection with an RNA virus, the DExD/H-box RNA helicases RIG-I (retinoic acid–inducible
gene I) and MDA5 (melanoma differentiation–associated gene 5) activate the …
gene I) and MDA5 (melanoma differentiation–associated gene 5) activate the …
[PDF][PDF] The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5
Y Sekine, R Hatanaka, T Watanabe, N Sono, S Iemura… - Molecular cell, 2012 - cell.com
Reactive oxygen species (ROS)-induced activation of Apoptosis signal-regulating kinase 1 (ASK1)
plays crucial roles in oxidative stress-mediated cell death through the activation of the …
plays crucial roles in oxidative stress-mediated cell death through the activation of the …
[HTML][HTML] Apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway-dependent cytoplasmic translocation of the orphan nuclear receptor NR4A2 is required for …
p38 mitogen-activated protein kinases (MAPKs) play important roles in various cellular stress
responses, including cell death, which is roughly categorized into apoptosis and necrosis. …
responses, including cell death, which is roughly categorized into apoptosis and necrosis. …
[HTML][HTML] Development and validation of the Japanese version of the Decisional Conflict Scale to investigate the value of pharmacists' information: a before and after …
…, K Azuma, T Yamaguchi, H Soeda, Y Sekine… - BMC Medical Informatics …, 2013 - Springer
Background The information provided in patient-centered care and shared decision-making
influences patients’ concerns and adherence to treatment. In the decision-making process, …
influences patients’ concerns and adherence to treatment. In the decision-making process, …