User profiles for Yuya Kiguchi

yuya kiguchi

Department of Computational Biology and Medical Sciences, 
the University of Tokyo
Verified email at edu.ku-tokyo.ac.jp
Cited by 776

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

…, C Luo, T Kawaguchi, I Motoo, S Narushima, Y Kiguchi… - Science, 2017 - science.org
Intestinal colonization by bacteria of oral origin has been correlated with several negative
health outcomes, including inflammatory bowel disease. However, a causal role of oral …

[HTML][HTML] Extensive gut virome variation and its associations with host and environmental factors in a population-level cohort

S Nishijima, N Nagata, Y Kiguchi, Y Kojima… - Nature …, 2022 - nature.com
Indigenous bacteriophage communities (virome) in the human gut have a huge impact on
the structure and function of gut bacterial communities (bacteriome), but virome variation at a …

Long-read metagenomics of multiple displacement amplified DNA of low-biomass human gut phageomes by SACRA pre-processing chimeric reads

Y Kiguchi, S Nishijima, N Kumar, M Hattori… - DNA …, 2021 - academic.oup.com
The human gut bacteriophage community (phageome) plays an important role in the host’s
health and disease; however, the entire structure is poorly understood, partly owing to the …

[HTML][HTML] Uncovering microbiomes of the rice phyllosphere using long-read metagenomic sequencing

S Masuda, P Gan, Y Kiguchi, M Anda, K Sasaki… - Communications …, 2024 - nature.com
The plant microbiome is crucial for plant growth, yet many important questions remain, such
as the identification of specific bacterial species in plants, their genetic content, and location …

[HTML][HTML] Recovery of microbial DNA by agar-containing solution from extremely low-biomass specimens including skin

R Kurokawa, H Masuoka, L Takayasu, Y Kiguchi… - Scientific Reports, 2023 - nature.com
Recovering a sufficient amount of microbial DNA from extremely low-biomass specimens,
such as human skin, to investigate the community structure of the microbiome remains …

Identification of the Set of Genes, Including Nonannotated morA, under the Direct Control of ModE in Escherichia coli

…, A Katayama, M Hiramatsu, Y Kiguchi… - Journal of …, 2013 - Am Soc Microbiol
ModE is the molybdate-sensing transcription regulator that controls the expression of genes
related to molybdate homeostasis in Escherichia coli . ModE is activated by binding …

Uncovering plant microbiomes using long-read metagenomic sequencing

S Masuda, P Gan, Y Kiguchi, M Anda, K Sasaki… - bioRxiv, 2023 - biorxiv.org
The microbiome of plants plays a pivotal role in their growth and health. Despite its importance,
many fundamental questions about the microbiome remain largely unanswered, such as …

Horizontal gene transfer shapes pathogenic bacteria in multiple sclerosis

T Yamamura, D Takewaki, Y Kiguchi, H Masuoka… - 2023 - researchsquare.com
Multiple sclerosis (MS) is an autoimmune demyelinating disease influenced by environmental
factors. Except during relapses, baseline neurological status is generally stable in the …

Lifelong temporal dynamics of the gut microbiome associated with longevity in mice

…, T Umeyama, R Kurokawa, Y Ogata, Y Kiguchi… - bioRxiv, 2022 - biorxiv.org
The effect of lifelong dynamics on host longevity of the gut microbiome is largely unknown.
Herein, we analyzed the longitudinal fecal samples of seven sibling mice across their lifespan …

Impact of chimera-less long reads on metagenomics of human gut viromes treated with multiple displacement amplification

Y Kiguchi, S Nishijima, N Kumar, M Hattori, W Suda - 2020 - researchsquare.com
Background: The ecological and biological features of the indigenous phage community (virome)
in the human gut microbiome are poorly understood, possibly due to many fragmented …