This paper extends robust principal component analysis (RPCA) to nonlinear manifolds.
Suppose that the observed data matrix is the sum of a sparse component and a component …

Evidence is mounting that the gut-brain axis plays an important role in mental diseases fueling
mechanistic investigations to provide a basis for future targeted interventions. However, …

The Collaborative Cross (CC) is a mouse recombinant inbred strain panel that is being
developed as a resource for mammalian systems genetics. Here we describe an experiment that …

Accumulating evidence suggests that gut microbiota plays a role in the pathogenesis of
schizophrenia via the microbiota–gut–brain axis. This study sought to investigate whether …

T cell proliferation and cytokine production are bioenergetically and biosynthetically costly.
The inability to meet these metabolic demands results in altered differentiation, accompanied …

Complex human traits are influenced by variation in regulatory DNA through mechanisms
that are not fully understood. Because regulatory elements are conserved between humans …

Glyceryl trinitrate (GTN), also known as nitroglycerin, has been used to treat angina and
heart failure for more than 130 years. Recently, it was shown that mitochondrial aldehyde …

Background Innate immune cells such as macrophages are abundantly present within malignant
ascites, where they share the microenvironment with ovarian cancer stem cells (CSC). …

Elevated levels of cytokines IL-1β and IL-6 are associated with severe COVID-19. Investigating
the underlying mechanisms, we find that while primary human airway epithelia (HAE) …

The incidence of human papillomavirus–positive (HPV + ) head and neck squamous cell
carcinoma (HNSCC) has surpassed that of cervical cancer and is projected to increase rapidly …