User profiles for Yuzhuo Wang
Yuzhuo Wang, Ph.D. FCAHSProfessor of Urologic Sciences, UBC Verified email at bccrc.ca Cited by 22044 |
Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets
…, K Park, SS Chae, A Sboner, TY MacDonald, Y Wang… - Cancer discovery, 2011 - AACR
Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of prostate cancer that
most commonly evolves from preexisting prostate adenocarcinoma (PCA). Using next-…
most commonly evolves from preexisting prostate adenocarcinoma (PCA). Using next-…
Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution
…, W Greenwood, K Leung, H Cheng, H Xue, Y Wang… - Nature, 2015 - nature.com
Human cancers, including breast cancers, comprise clones differing in mutation content.
Clones evolve dynamically in space and time following principles of Darwinian evolution 1 , 2 , …
Clones evolve dynamically in space and time following principles of Darwinian evolution 1 , 2 , …
[HTML][HTML] The long and short non-coding RNAs modulating EZH2 signaling in cancer
Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in encoding
proteins. However, they participate in developmental and biological processes and their …
proteins. However, they participate in developmental and biological processes and their …
Cancer‐generated lactic acid: a regulatory, immunosuppressive metabolite?
…, CC Collins, PW Gout, Y Wang - The Journal of …, 2013 - Wiley Online Library
The common preference of cancers for lactic acid‐generating metabolic energy pathways
has led to proposals that their reprogrammed metabolism confers growth advantages such as …
has led to proposals that their reprogrammed metabolism confers growth advantages such as …
[HTML][HTML] Lactic acid and an acidic tumor microenvironment suppress anticancer immunity
JX Wang, SYC Choi, X Niu, N Kang, H Xue… - International journal of …, 2020 - mdpi.com
Immune evasion and altered metabolism, where glucose utilization is diverted to increased
lactic acid production, are two fundamental hallmarks of cancer. Although lactic acid has long …
lactic acid production, are two fundamental hallmarks of cancer. Although lactic acid has long …
Androgen receptor gene aberrations in circulating cell-free DNA: biomarkers of therapeutic resistance in castration-resistant prostate cancer
…, J Youngren, P Paris, G Thomas, EJ Small, Y Wang… - Clinical cancer …, 2015 - AACR
Purpose: Although novel agents targeting the androgen–androgen receptor (AR) axis have
altered the treatment paradigm of metastatic castration-resistant prostate cancer (mCRPC), …
altered the treatment paradigm of metastatic castration-resistant prostate cancer (mCRPC), …
Malignant transformation in a nontumorigenic human prostatic epithelial cell line
SW Hayward, Y Wang, M Cao, YK Hom, B Zhang… - Cancer research, 2001 - AACR
The human prostatic epithelial cell line BPH-1 is normally nontumorigenic in nude mice.
The present report demonstrates that this cell line can be permanently transformed by its …
The present report demonstrates that this cell line can be permanently transformed by its …
[HTML][HTML] Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer
…, IJ Apel, L McMurry, F Su, R Wang, S Zelenka-Wang… - Nature, 2022 - nature.com
The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin
remodelling 1 and is altered in over 20% of cancers 2 , 3 . Here we developed a proteolysis-…
remodelling 1 and is altered in over 20% of cancers 2 , 3 . Here we developed a proteolysis-…
High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development
Standardized and reproducible preclinical models that recapitulate the dynamics of prostate
cancer are urgently needed. We established a bank of transplantable patient-derived …
cancer are urgently needed. We established a bank of transplantable patient-derived …
Cell differentiation lineage in the prostate
Y Wang, SW Hayward, M Cao, KA Thayer, GR Cunha - Differentiation, 2001 - Elsevier
Prostatic epithelium consists mainly of luminal and basal cells, which are presumed to
differentiate from common progenitor/stem cells. We hypothesize that progenitor/stem cells are …
differentiate from common progenitor/stem cells. We hypothesize that progenitor/stem cells are …