Microglia-neuron interactions play a crucial role in several neurological disorders characterized
by altered neural network excitability, such as epilepsy and neuropathic pain. While a …

Neuropathic pain that occurs after peripheral nerve injury depends on the hyperexcitability
of neurons in the dorsal horn of the spinal cord 1 , 2 , 3 . Spinal microglia stimulated by ATP …

Fast synaptic inhibition relies on tight regulation of intracellular Cl − . Chloride dysregulation
is implicated in several neurological and psychiatric disorders. Beyond mere disinhibition, …

The spinal dorsal horn is the first level of the CNS in which nociceptive input from sensory
afferents is integrated and transmitted. Although inhibitory control in this region has a crucial …

Chloride homeostasis is a critical determinant of the strength and robustness of inhibition
mediated by GABA A receptors (GABA A Rs). The impact of changes in steady state Cl − …

… In the version of this article initially published online, Yves De Koninck’s name was
misspelled in the author list. The original version listed Yves DeKoninck. The error has been …

Neuropathic pain resulting from damage to or dysfunction of peripheral nerves is not well
understood and difficult to treat. Although CNS hyperexcitability is a critical component, recent …

A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the
gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing …

Peripheral nerve injury can induce spinal microglial/astrocyte activation. Substances released
by activated glial cells excite spinal nociceptive neurons. Pharmacological disruption of …

Background: The measurement of mechanosensitivity is a key method for the study of pain
in animal models. This is often accomplished with the use of von Frey filaments in an up-…